| Unique identifier for interactor A | uniprotkb:P00533 |
| Unique identifier for interactor B | uniprotkb:P22681 |
| Alternative identifier for interactor A | intact:EBI-297353 uniprotkb:Q9BZS2 uniprotkb:Q9GZX1 uniprotkb:Q9H2C9 uniprotkb:Q9H3C9 uniprotkb:Q9UMD7 uniprotkb:Q9UMD8 uniprotkb:Q9UMG5 uniprotkb:O00688 uniprotkb:O00732 uniprotkb:P06268 uniprotkb:Q14225 uniprotkb:Q92795 intact:EBI-28985169 uniprotkb:Q68GS5 ensembl:ENSP00000275493.2 |
| Alternative identifier for interactor B | intact:EBI-518228 ensembl:ENSP00000264033.3 uniprotkb:A3KMP8 |
| Aliases for A | psi-mi:egfr_human(display_long) uniprotkb:ERBB1(gene name synonym) uniprotkb:EGFR(gene name) psi-mi:EGFR(display_short) uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym) uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym) uniprotkb:ERBB(gene name synonym) uniprotkb:HER1(gene name synonym) |
| Aliases for B | psi-mi:cbl_human(display_long) uniprotkb:Signal transduction protein CBL(gene name synonym) uniprotkb:Proto-oncogene c-Cbl(gene name synonym) uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym) uniprotkb:RING finger protein 55(gene name synonym) uniprotkb:CBL(gene name) psi-mi:CBL(display_short) uniprotkb:CBL2(gene name synonym) uniprotkb:RNF55(gene name synonym) uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0007"(anti tag coimmunoprecipitation) |
| First author | Song et al. (2016) |
| Identifier of the publication | imex:IM-25318 pubmed:27059931 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-11783267 imex:IM-25318-1 |
| Confidence score | intact-miscore:0.96 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f3a comment:"\"As shown in Fig. 3A, B, when compared with EGFR, EGFRvA weakly interacted with c-Cbl. It was noteworthy that the truncated mutant of EGFR (aa 1–1066), which contained the sequence same for EGFR and EGFRvA, had weak binding ability to c-Cbl as EGFRvA did. This implies that the loss of C-terminal sequence is the reason why EGFRvA binds less to c-Cbl than EGFR.\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293t) taxid:9606(Homo sapiens HEK293T embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2016/06/19 |
| Update date | 2024/07/10 |
| negative Boolean value | false |
| Feature(s) for interactor A | sufficient binding region:1066-1210 ha tag:?-? mutation decreasing interaction:1069-1069 |
| Feature(s) for interactor B | flag tag:?-? |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Anti tag western blot |
| Participant identification method for interactor B | Anti tag western blot |