| Unique identifier for interactor A | uniprotkb:P49768 |
| Unique identifier for interactor B | uniprotkb:Q9QXT8 |
| Alternative identifier for interactor A | intact:EBI-297277 uniprotkb:O95465 uniprotkb:Q14762 uniprotkb:Q15719 uniprotkb:Q15720 uniprotkb:Q96P33 uniprotkb:Q9UIF0 uniprotkb:B2R6D3 ensembl:ENSP00000326366.5 ensembl:ENSP00000451915.2 ensembl:ENSP00000514903.1 ensembl:ENSP00000514904.1 ensembl:ENSP00000514905.1 ensembl:ENSP00000514933.1 ensembl:ENSP00000514944.1 ensembl:ENSP00000514948.1 ensembl:ENSP00000514950.1 ensembl:ENSP00000514966.1 ensembl:ENSP00000514968.1 |
| Alternative identifier for interactor B | intact:EBI-11720427 uniprotkb:Q924L0 uniprotkb:Q99PH9 uniprotkb:Q99PI0 uniprotkb:Q99PI2 uniprotkb:Q99PI3 uniprotkb:Q9JHZ5 ensembl:ENSMUSP00000099504.5 |
| Aliases for A | psi-mi:psn1_human(display_long) uniprotkb:PSEN1(gene name) psi-mi:PSEN1(display_short) uniprotkb:AD3(gene name synonym) uniprotkb:PS1(gene name synonym) uniprotkb:PSNL1(gene name synonym) uniprotkb:Protein S182(gene name synonym) |
| Aliases for B | psi-mi:csen_mouse(display_long) uniprotkb:A-type potassium channel modulatory protein 3(gene name synonym) uniprotkb:Kcnip3(gene name) psi-mi:Kcnip3(display_short) uniprotkb:Csen(gene name synonym) uniprotkb:Dream(gene name synonym) uniprotkb:Kchip3(gene name synonym) uniprotkb:DRE-antagonist modulator(gene name synonym) uniprotkb:Kv channel-interacting protein 3(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0017"(classical fluorescence spectroscopy) |
| First author | Pham et al. (2016) |
| Identifier of the publication | imex:IM-25306 pubmed:27009418 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:10090(mouse) taxid:10090(Mus musculus) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-11720536 imex:IM-25306-1 |
| Confidence score | intact-miscore:0.44 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:t1 f2 comment:"\"HL9 binds to Ca2+DREAM and Mg2+Ca2+DREAM with a similar Kd of 0.6 μm. In the absence of Ca2+, a weak interaction was determined for binding of HL9 to ApoDREAM (Kd = 183 ± 12 μm), whereas the Kd value for HL9 association with Mg2+DREAM was found to be 29 ± 2 μm.\"" comment:"\"To investigate the mechanism by which Ca2+ binding to EF-hands 3 and 4 in DREAM mediates DREAM and HL9 interactions, binding of HL9 to DREAM-E234Q and DREAM-E186Q were studied. Titration data demonstrate that HL9 binds to DREAM-E234Q in the presence of Ca2+ and Ca2+/Mg2+ with a Kd of 8 μm, whereas a weaker binding (Kd = 32 μm) was observed for DREAM-E186Q mutant (Table 1).\"" curation depth:imex curation full coverage:Only protein-protein interactions dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | kd:0.6x10^-6(molar) |
| Creation date | 2016/06/06 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | binding-associated region:445-467 |
| Feature(s) for interactor B | mutation decreasing interaction:234-234 mutation decreasing interaction:186-186 binding-associated region:65-161 |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Predetermined participant |
| Participant identification method for interactor B | Predetermined participant |