| Unique identifier for interactor A | uniprotkb:P01034 |
| Unique identifier for interactor B | uniprotkb:P01034 |
| Alternative identifier for interactor A | intact:EBI-948622 uniprotkb:Q6FGW9 uniprotkb:B2R5J9 ensembl:ENSP00000366124.3 ensembl:ENSP00000381446.1 ensembl:ENSP00000381448.1 uniprotkb:D3DW42 |
| Alternative identifier for interactor B | intact:EBI-948622 uniprotkb:Q6FGW9 uniprotkb:B2R5J9 ensembl:ENSP00000366124.3 ensembl:ENSP00000381446.1 ensembl:ENSP00000381448.1 uniprotkb:D3DW42 |
| Aliases for A | psi-mi:cytc_human(display_long) uniprotkb:Cystatin-3(gene name synonym) uniprotkb:Neuroendocrine basic polypeptide(gene name synonym) uniprotkb:Gamma-trace(gene name synonym) uniprotkb:Post-gamma-globulin(gene name synonym) uniprotkb:CST3(gene name) psi-mi:CST3(display_short) |
| Aliases for B | psi-mi:cytc_human(display_long) uniprotkb:Cystatin-3(gene name synonym) uniprotkb:Neuroendocrine basic polypeptide(gene name synonym) uniprotkb:Gamma-trace(gene name synonym) uniprotkb:Post-gamma-globulin(gene name synonym) uniprotkb:CST3(gene name) psi-mi:CST3(display_short) |
| Interaction detection methods | psi-mi:"MI:0017"(classical fluorescence spectroscopy) |
| First author | Sant'Anna et al. (2016) |
| Identifier of the publication | pubmed:26865059 imex:IM-25095 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-11686045 imex:IM-25095-1 |
| Confidence score | intact-miscore:0.77 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | comment:"\"As shown in Fig. 2A, there was a proportional increase in Thioflavin-T (Th-T) emission at increasing concentrations of the peptide, suggesting formation of amyloid-like aggregates in solution. Congo red (CR) binding assays were also performed to confirm the presence of amyloid-like aggregates (Fig. 2A, inset). In order to follow the aggregation kinetics of the signal peptide, increasing concentrations of the peptide were incubated with Th-T and its fluorescence emission was collected over time (Fig. 2B). Notably, even at very low peptide concentration such as 5 μm, maximum emission of Th-T was attained in the first acquisition points, with no further change in the fluorescence signal of the probe even after 3 days under aggregation conditions. This suggests that aggregation of the signal peptide of cystatin C is very fast.\"" figure legend:f2 curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2016/04/08 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Predetermined participant |
| Participant identification method for interactor B | Predetermined participant |