Curation Details
Interaction ID: IM-24941-3

Unique identifier for interactor Auniprotkb:P02768
Unique identifier for interactor Buniprotkb:P02768
Alternative identifier for interactor Aintact:EBI-714423
uniprotkb:Q645G4
uniprotkb:O95574
uniprotkb:P04277
uniprotkb:Q13140
uniprotkb:Q68DN5
uniprotkb:Q6UXK4
uniprotkb:Q86YG0
uniprotkb:Q9P157
uniprotkb:Q9P1I7
uniprotkb:Q9UHS3
uniprotkb:Q9UJZ0
intact:EBI-7301844
intact:MINT-1161169
uniprotkb:E7ESS9
uniprotkb:Q8IUK7
ensembl:ENSP00000295897.4
Alternative identifier for interactor Bintact:EBI-714423
uniprotkb:Q645G4
uniprotkb:O95574
uniprotkb:P04277
uniprotkb:Q13140
uniprotkb:Q68DN5
uniprotkb:Q6UXK4
uniprotkb:Q86YG0
uniprotkb:Q9P157
uniprotkb:Q9P1I7
uniprotkb:Q9UHS3
uniprotkb:Q9UJZ0
intact:EBI-7301844
intact:MINT-1161169
uniprotkb:E7ESS9
uniprotkb:Q8IUK7
ensembl:ENSP00000295897.4
Aliases for Apsi-mi:albu_human(display_long)
uniprotkb:GIG42(orf name)
uniprotkb:ALB(gene name)
psi-mi:ALB(display_short)
uniprotkb:PRO0903(orf name)
uniprotkb:PRO1708(orf name)
uniprotkb:PRO2044(orf name)
uniprotkb:PRO2619(orf name)
uniprotkb:PRO2675(orf name)
uniprotkb:UNQ696/PRO1341(orf name)
uniprotkb:GIG20(orf name)
Aliases for Bpsi-mi:albu_human(display_long)
uniprotkb:GIG42(orf name)
uniprotkb:ALB(gene name)
psi-mi:ALB(display_short)
uniprotkb:PRO0903(orf name)
uniprotkb:PRO1708(orf name)
uniprotkb:PRO2044(orf name)
uniprotkb:PRO2619(orf name)
uniprotkb:PRO2675(orf name)
uniprotkb:UNQ696/PRO1341(orf name)
uniprotkb:GIG20(orf name)
Interaction detection methodspsi-mi:"MI:0017"(classical fluorescence spectroscopy)
First authorSharma et al. (2015)
Identifier of the publicationpubmed:26554815
imex:IM-24941
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-11476980
imex:IM-24941-3
Confidence scoreintact-miscore:0.76
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f1b f3a f3b f3c
comment:"\"Indeed, as per our hypothesis, the HSA amyloid aggregates showed self-seeding at 50 C as observed by amyloid-like increase in ThT fluorescence intensity (Fig. 1B)\""
comment:"\"The fractions containing predominantly HSA dimers were pooled and further analyzed for amyloid forming ability under conditions as described for HSA monomer. The HSA dimers were found to aggregate and exhibit amyloid-like ThT fluorescence emission and excitation similar to HSA monomer aggregates (Fig. 3A and B) [21]. Also, when added with Congo red, the dimer aggregates caused red shift in Congo red absorption maximum from 480 nm to 540 nm accompanied by increase in absorption intensity near 540 nm suggesting amyloid-like nature of the aggregates (Fig. 3C)\""
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2016/01/12
Update date2024/07/17
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APredetermined participant
Participant identification method for interactor BPredetermined participant