| Unique identifier for interactor A | uniprotkb:Q9UBZ9 |
| Unique identifier for interactor B | uniprotkb:Q6NZ36 |
| Alternative identifier for interactor A | intact:EBI-7353917 intact:MINT-140323 uniprotkb:Q53SI7 uniprotkb:O95941 uniprotkb:Q9NUP2 uniprotkb:Q9C0J4 ensembl:ENSP00000258428.3 |
| Alternative identifier for interactor B | intact:EBI-2817693 uniprotkb:F2Z2L4 uniprotkb:A8MQT6 uniprotkb:Q6ZT64 uniprotkb:A6PW40 uniprotkb:Q71M24 uniprotkb:A6PW39 uniprotkb:A6PW41 uniprotkb:Q96ND7 intact:EBI-28984154 ensembl:ENSP00000367808.4 |
| Aliases for A | psi-mi:rev1_human(display_long) uniprotkb:REV1(gene name) psi-mi:REV1(display_short) uniprotkb:REV1L(gene name synonym) uniprotkb:Rev1-like terminal deoxycytidyl transferase(gene name synonym) uniprotkb:Alpha integrin-binding protein 80(gene name synonym) |
| Aliases for B | psi-mi:fap20_human(display_long) uniprotkb:FANCA-associated protein of 20 kDa(gene name synonym) uniprotkb:Fanconi anemia-associated protein of 20 kDa(gene name synonym) uniprotkb:FP7162(orf name) uniprotkb:FAAP20(gene name) psi-mi:FAAP20(display_short) uniprotkb:C1orf86(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0077"(nuclear magnetic resonance) |
| First author | Lim et al. (2015) |
| Identifier of the publication | pubmed:26318859 imex:IM-24702 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-11360799 imex:IM-24702-3 |
| Confidence score | intact-miscore:0.54 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f4 f5 sf5 sf9 comment:"\"We decided to examine the effect of the interaction between UBZ4 and ubiquitin on the BRCT binding to UBZ4. We performed an NMR titration experiment, questioning whether ubiquitin and BRCT compete for the interaction with UBZ4 or if the binding surface of BRCT is separate from the ubiquitin binding site on UBZ4. Unlabeled BRCT was titrated into a 1:2 mixture of 15N-UBZ4 and unlabeled ubiquitin. As shown in Fig. 4A and B, addition of BRCT resulted in peak broadening and CSP in some amide resonances, indicating that BRCT can bind to the UBZ4–ubiquitin complex and that the binding is in the intermediate to fast exchange on the NMR time scale. Moreover, this result did not show the peaks returning to the position of 15N-UBZ4 bound to BRCT, implying that BRCT does not compete with ubiquitin or displace it from a single binding site\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | kd:39586.0x10^-6(molar) |
| Creation date | 2015/11/04 |
| Update date | 2015/11/04 |
| negative Boolean value | false |
| Feature(s) for interactor A | binding-associated region:44-132 |
| Feature(s) for interactor B | binding-associated region:133-180 |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Predetermined participant |
| Participant identification method for interactor B | Predetermined participant |