| Unique identifier for interactor A | uniprotkb:Q96SW2 |
| Unique identifier for interactor B | uniprotkb:Q13422 |
| Alternative identifier for interactor A | intact:EBI-2510250 uniprotkb:B2R6H4 uniprotkb:C9IZA9 uniprotkb:C9JAH6 uniprotkb:Q6NVZ0 uniprotkb:Q6AI62 uniprotkb:Q9UHW4 ensembl:ENSP00000231948.4 |
| Alternative identifier for interactor B | intact:EBI-745305 ensembl:ENSP00000331614.3 uniprotkb:Q53XL2 uniprotkb:B4E0Z1 uniprotkb:A4D260 uniprotkb:D3DVM5 uniprotkb:Q69BM4 intact:EBI-28969803 uniprotkb:O00598 uniprotkb:Q8WVA3 |
| Aliases for A | psi-mi:crbn_human(display_long) uniprotkb:CRBN(gene name) psi-mi:CRBN(display_short) uniprotkb:AD-006(orf name) |
| Aliases for B | psi-mi:ikzf1_human(display_long) uniprotkb:Ikaros family zinc finger protein 1(gene name synonym) uniprotkb:Lymphoid transcription factor LyF-1(gene name synonym) uniprotkb:IKZF1(gene name) psi-mi:IKZF1(display_short) uniprotkb:IK1(gene name synonym) uniprotkb:IKAROS(gene name synonym) uniprotkb:LYF1(gene name synonym) uniprotkb:ZNFN1A1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0096"(pull down) |
| First author | Liu et al. (2015) |
| Identifier of the publication | imex:IM-24529 pubmed:26183205 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-11189384 imex:IM-24529-1 |
| Confidence score | intact-miscore:0.40 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f3a comment:"\"We coexpressed FLAG-IKZF1 with Strep-CRBN in HEK293T cells and treated the cells with lenalidomide, DRB, and Rosc along with a proteasome inhibitor MG132. We then used Strep-Tactin agarose beads to affinity-purify Strep-CRBN and its interacting proteins and blotted the purified samples with anti-FLAG and anti-CRBN antibodies. Immunoblotting results showed that IKZF1 was readily detected in the pulldown when the cells were treated with lenalidomide (Fig. 3A).\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2015/09/23 |
| Update date | 2015/09/23 |
| negative Boolean value | false |
| Feature(s) for interactor A | strep tag:?-? |
| Feature(s) for interactor B | flag tag:?-? |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |