Curation Details
Interaction ID: IM-24273-9

Unique identifier for interactor Auniprotkb:Q9Y4G6
Unique identifier for interactor Buniprotkb:P18084
Alternative identifier for interactor Aintact:EBI-1220811
uniprotkb:A6NLB8
ensembl:ENSP00000453508.1
ensembl:ENSP00000490662.2
Alternative identifier for interactor Bintact:EBI-1223434
uniprotkb:B2RD70
ensembl:ENSP00000296181.4
uniprotkb:B0LPF8
Aliases for Apsi-mi:tln2_human(display_long)
uniprotkb:TLN2(gene name)
psi-mi:TLN2(display_short)
uniprotkb:KIAA0320(gene name synonym)
Aliases for Bpsi-mi:itb5_human(display_long)
uniprotkb:ITGB5(gene name)
psi-mi:ITGB5(display_short)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorHu et al. (2014)
Identifier of the publicationpubmed:25448675
imex:IM-24273
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-9843752
imex:IM-24273-9
Confidence scoreintact-miscore:0.40
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f2i
comment:"\"we then performed a co-IP assay and found that FRMD5 promoted Kindlin 2 interaction with integrin but inhibited the interaction between Talin head and integrin (Fig. 2H and I). These findings indicated that FRMD5 interferes with the interaction of integrin cytoplasmic tails with their binding partners\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-a_549)
taxid:9606(Homo sapiens A549 lung carcinoma cell)
Parameters of the interaction-
Creation date2014/10/09
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Aflag tag:?-?
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AAnti tag western blot
Participant identification method for interactor BWestern blot