Curation Details
Interaction ID: IM-24039-17

Unique identifier for interactor Auniprotkb:Q60795
Unique identifier for interactor Buniprotkb:Q9Z2X8
Alternative identifier for interactor Aintact:EBI-642563
ensembl:ENSMUSP00000099733.5
uniprotkb:Q3UQK0
Alternative identifier for interactor Bintact:EBI-647110
uniprotkb:Q3U243
uniprotkb:Q3U8N7
uniprotkb:Q547S3
uniprotkb:Q6ZQI6
uniprotkb:Q8BQY3
ensembl:ENSMUSP00000062467.5
ensembl:ENSMUSP00000131029.2
ensembl:ENSMUSP00000141807.2
ensembl:ENSMUSP00000141840.2
Aliases for Apsi-mi:nf2l2_mouse(display_long)
uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)
uniprotkb:Nfe2l2(gene name)
psi-mi:Nfe2l2(display_short)
uniprotkb:Nrf2(gene name synonym)
Aliases for Bpsi-mi:keap1_mouse(display_long)
uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)
uniprotkb:Keap1(gene name)
psi-mi:Keap1(display_short)
uniprotkb:Inrf2(gene name synonym)
uniprotkb:Kiaa0132(gene name synonym)
Interaction detection methodspsi-mi:"MI:0096"(pull down)
First authorFukutomi et al. (2014)
Identifier of the publicationpubmed:24366543
imex:IM-24039
NCBI Taxonomy identifier for interactor Ataxid:10090(mouse)
taxid:10090(Mus musculus)
NCBI Taxonomy identifier for interactor Btaxid:10090(mouse)
taxid:10090(Mus musculus)
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-10760126
imex:IM-24039-17
Confidence scoreintact-miscore:0.82
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f3
comment:"\"the combined deletion analysis revealed that the region spanning Met17 to Tyr46 is essential and sufficient for Keap1 binding (Fig. 3B). We refer to this region as Nrf2-DLG. The results also indicate that the region corresponding to Met17 to Gln51 retains slightly stronger Keap1-binding activity. Therefore, we designated Met17 to Gln51 as the extended DLG motif of Nrf2 (Nrf2-DLGex) in this study.\""
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2015/03/30
Update date2024/09/12
negative Boolean valuefalse
Feature(s) for interactor Asufficient binding region:17-46
tandem tag:?-?
Feature(s) for interactor Bhis tag:?-?
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AMolecular weight estimation by staining
Participant identification method for interactor BMolecular weight estimation by staining