Curation Details
Interaction ID: IM-23861-2

Unique identifier for interactor Auniprotkb:P08253
Unique identifier for interactor Buniprotkb:Q80W65
Alternative identifier for interactor Aintact:EBI-1033518
uniprotkb:B2R6U1
uniprotkb:Q9UCJ8
uniprotkb:E9PE45
uniprotkb:B4DWH3
ensembl:ENSP00000219070.4
Alternative identifier for interactor Bintact:EBI-10634657
uniprotkb:B1AZI4
uniprotkb:Q3UEH7
uniprotkb:Q8BXW9
uniprotkb:Q8CFT6
ensembl:ENSMUSP00000055757.6
Aliases for Apsi-mi:mmp2_human(display_long)
uniprotkb:MMP2(gene name)
psi-mi:MMP2(display_short)
uniprotkb:CLG4A(gene name synonym)
uniprotkb:72 kDa gelatinase(gene name synonym)
uniprotkb:Matrix metalloproteinase-2(gene name synonym)
uniprotkb:Gelatinase A(gene name synonym)
uniprotkb:TBE-1(gene name synonym)
Aliases for Bpsi-mi:pcsk9_mouse(display_long)
uniprotkb:Pcsk9(gene name)
psi-mi:Pcsk9(display_short)
uniprotkb:Narc1(gene name synonym)
uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)
uniprotkb:Proprotein convertase 9(gene name synonym)
uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)
Interaction detection methodspsi-mi:"MI:0415"(enzymatic study)
First authorWang et al. (2015)
Identifier of the publicationpubmed:25613181
imex:IM-23861
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:10090(mouse)
taxid:10090(Mus musculus)
Interaction typespsi-mi:"MI:0194"(cleavage reaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-10634649
imex:IM-23861-2
Confidence scoreintact-miscore:0.44
Complex expansion-
Biological role AEnzyme
Biological role BEnzyme target
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:sf2 f2b st2
comment:"\"two putative cleavage sites both occurring at Gly;Ile bonds proximal to the C-terminus of PCSK9 (Supplementary Fig. 2)\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2015/02/16
Update date2015/02/24
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor Bprotein modification:397-397
protein modification:617-617
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APredetermined participant
Participant identification method for interactor BIdentification by mass spectrometry