| Unique identifier for interactor A | uniprotkb:P02545 |
| Unique identifier for interactor B | uniprotkb:Q00613 |
| Alternative identifier for interactor A | intact:EBI-351935 uniprotkb:Q5TCJ3 ensembl:ENSP00000355292.6 ensembl:ENSP00000357283.4 ensembl:ENSP00000502256.1 ensembl:ENSP00000506771.1 uniprotkb:D3DVB0 intact:EBI-28988787 uniprotkb:B4DI32 uniprotkb:E7EUI9 uniprotkb:P02546 uniprotkb:Q969I8 uniprotkb:Q96JA2 uniprotkb:D6RAQ3 uniprotkb:Q5I6Y4 uniprotkb:Q5I6Y6 uniprotkb:Q6UYC3 uniprotkb:Q5TCJ2 |
| Alternative identifier for interactor B | intact:EBI-719620 ensembl:ENSP00000431512.1 ensembl:ENSP00000493830.1 uniprotkb:A8MW26 uniprotkb:Q53XT4 uniprotkb:A8K4L0 |
| Aliases for A | psi-mi:lmna_human(display_long) uniprotkb:LMNA(gene name) psi-mi:LMNA(display_short) uniprotkb:LMN1(gene name synonym) |
| Aliases for B | psi-mi:hsf1_human(display_long) uniprotkb:Heat shock transcription factor 1(gene name synonym) uniprotkb:HSF1(gene name) psi-mi:HSF1(display_short) uniprotkb:HSTF1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0029"(cosedimentation through density gradient) |
| First author | Dai et al. (2015) |
| Identifier of the publication | imex:IM-23858 pubmed:25425574 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0403"(colocalization) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-10682932 imex:IM-23858-3 |
| Confidence score | intact-miscore:0.35 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f1j comment:"\"Next, we investigated whether metformin affected HSF1 nuclear translocation, a prerequisite for its DNA binding. As expected, heat shock caused most HSF1 proteins to translocate from the cytoplasm to the nucleus (Fig 1J). Importantly, metformin impeded this translocation (Fig 1J). Thus, metformin impairs HSF1–DNA binding at least in part through blockade of its nuclear translocation.\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293t) taxid:9606(Homo sapiens HEK293T embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2015/02/18 |
| Update date | 2015/02/20 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |