| Unique identifier for interactor A | uniprotkb:Q00613 |
| Unique identifier for interactor B | uniprotkb:P02545 |
| Alternative identifier for interactor A | intact:EBI-719620 uniprotkb:A8MW26 uniprotkb:Q53XT4 uniprotkb:A8K4L0 ensembl:ENSP00000431512.1 ensembl:ENSP00000493830.1 |
| Alternative identifier for interactor B | intact:EBI-351935 uniprotkb:B4DI32 uniprotkb:E7EUI9 uniprotkb:P02546 uniprotkb:Q969I8 uniprotkb:Q96JA2 uniprotkb:D6RAQ3 uniprotkb:Q5I6Y4 uniprotkb:Q5I6Y6 uniprotkb:Q6UYC3 uniprotkb:Q5TCJ2 uniprotkb:Q5TCJ3 uniprotkb:D3DVB0 intact:EBI-28988787 ensembl:ENSP00000355292.6 ensembl:ENSP00000357283.4 ensembl:ENSP00000502256.1 ensembl:ENSP00000506771.1 |
| Aliases for A | psi-mi:hsf1_human(display_long) uniprotkb:Heat shock transcription factor 1(gene name synonym) uniprotkb:HSF1(gene name) psi-mi:HSF1(display_short) uniprotkb:HSTF1(gene name synonym) |
| Aliases for B | psi-mi:lmna_human(display_long) uniprotkb:LMNA(gene name) psi-mi:LMNA(display_short) uniprotkb:LMN1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0029"(cosedimentation through density gradient) |
| First author | Dai et al. (2015) |
| Identifier of the publication | imex:IM-23858 pubmed:25425574 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0403"(colocalization) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-10682923 imex:IM-23858-2 |
| Confidence score | intact-miscore:0.35 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f3i f3j comment:"\"Despite no impacts on HSF1 expression, AMPKaCA impaired constitutive nuclear translocation of HSF1WT in HEK293T cells, indicated by diminished nuclear–cytoplasmic ratio of HSF1 levels (Fig 3I). S121A mutation not only enhanced HSF1 nuclear translocation under basal conditions but also rendered HSF1 resistant to the effect of AMPKaCA (Fig 3I). Similarly, while metformin impaired HSF1WT nuclear translocation, it exerted little effect on HSF1S121A mutants (Fig 3J). Thus, this defect in nuclear translocation due to Ser121 phosphorylation at least in part contributes to reduced HSF1–DNA binding\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293t) taxid:9606(Homo sapiens HEK293T embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2015/02/18 |
| Update date | 2024/09/12 |
| negative Boolean value | false |
| Feature(s) for interactor A | flag tag:?-? |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Anti tag western blot |
| Participant identification method for interactor B | Western blot |