| Unique identifier for interactor A | uniprotkb:P01034 |
| Unique identifier for interactor B | uniprotkb:P01034 |
| Alternative identifier for interactor A | intact:EBI-948622 uniprotkb:Q6FGW9 uniprotkb:B2R5J9 ensembl:ENSP00000366124.3 ensembl:ENSP00000381446.1 ensembl:ENSP00000381448.1 uniprotkb:D3DW42 |
| Alternative identifier for interactor B | intact:EBI-948622 uniprotkb:Q6FGW9 uniprotkb:B2R5J9 ensembl:ENSP00000366124.3 ensembl:ENSP00000381446.1 ensembl:ENSP00000381448.1 uniprotkb:D3DW42 |
| Aliases for A | psi-mi:cytc_human(display_long) uniprotkb:Cystatin-3(gene name synonym) uniprotkb:Neuroendocrine basic polypeptide(gene name synonym) uniprotkb:Gamma-trace(gene name synonym) uniprotkb:Post-gamma-globulin(gene name synonym) uniprotkb:CST3(gene name) psi-mi:CST3(display_short) |
| Aliases for B | psi-mi:cytc_human(display_long) uniprotkb:Cystatin-3(gene name synonym) uniprotkb:Neuroendocrine basic polypeptide(gene name synonym) uniprotkb:Gamma-trace(gene name synonym) uniprotkb:Post-gamma-globulin(gene name synonym) uniprotkb:CST3(gene name) psi-mi:CST3(display_short) |
| Interaction detection methods | psi-mi:"MI:0114"(x-ray crystallography) |
| First author | Tsiolaki et al. (2015) |
| Identifier of the publication | pubmed:25479090 imex:IM-23829 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-10169805 imex:IM-23829-1 |
| Confidence score | intact-miscore:0.77 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f4 comment:"\"we determined a novel aggregation-potent segment of HCC, 47LQVVR51, which was initially predicted as such, by implementing AMYLPRED, our aggregation propensity prediction algorithm [28]. This ‘aggregationprone’ peptide segment was synthesized (see Section 2) and here we present experimental results, verifying its strong aggregation propensity to form amyloid fibrils.\"" comment:"\"X-ray diffraction patterns from fibers formed from LQVVR peptide fibrils showed two strong reflections at 4.62 Å and 11.63 Å (Fig. 4). These reflections appear as rings due to the poor alignment of the constituent fibrils.\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2015/02/12 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | binding-associated region:73-77 |
| Feature(s) for interactor B | binding-associated region:73-77 |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Peptide synthesis |
| Participant identification method for interactor B | Peptide synthesis |