| Unique identifier for interactor A | uniprotkb:O95782 |
| Unique identifier for interactor B | uniprotkb:Q7Z3C6 |
| Alternative identifier for interactor A | intact:EBI-353552 uniprotkb:Q96CI7 uniprotkb:Q96PP6 uniprotkb:Q96PP7 uniprotkb:Q9H070 intact:EBI-28973302 ensembl:ENSP00000351926.4 |
| Alternative identifier for interactor B | intact:EBI-727146 uniprotkb:Q6P0N7 uniprotkb:Q7Z317 uniprotkb:Q7Z320 uniprotkb:Q8NDK6 uniprotkb:Q8WU65 uniprotkb:Q9BVL5 uniprotkb:Q9H6L1 uniprotkb:Q9HAG7 uniprotkb:Q3ZAQ6 ensembl:ENSP00000355173.4 ensembl:ENSP00000379983.2 ensembl:ENSP00000386710.1 |
| Aliases for A | psi-mi:ap2a1_human(display_long) uniprotkb:AP2A1(gene name) psi-mi:AP2A1(display_short) uniprotkb:ADTAA(gene name synonym) uniprotkb:CLAPA1(gene name synonym) uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym) uniprotkb:Alpha1-adaptin(gene name synonym) uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym) uniprotkb:Alpha-adaptin A(gene name synonym) uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym) uniprotkb:100 kDa coated vesicle protein A(gene name synonym) uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym) |
| Aliases for B | psi-mi:atg9a_human(display_long) uniprotkb:APG9-like 1(gene name synonym) uniprotkb:ATG9A(gene name) psi-mi:ATG9A(display_short) uniprotkb:APG9L1(gene name synonym) uniprotkb:mATG9(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0416"(fluorescence microscopy) |
| First author | Popovic et al. (2014) |
| Identifier of the publication | pubmed:24603492 imex:IM-23790 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0403"(colocalization) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-10105731 imex:IM-23790-16 |
| Confidence score | intact-miscore:0.43 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f3d f5a comment:"\"Moreover, TBC1D5 and ATG9 co-localized with the AP2 complex (Fig 3D, Supplementary Fig S6A). Importantly, co- localization of ATG9 with AP2 was enhanced during autophagy (Fig 3E, Supplementary Fig S6B) and readily disturbed upon the depletion of TBC1D5 (Supplementary Fig S6B).\"" comment:"\"Next, we treated cells with the Dynamin 2 inhibitor Dynasore [25], which led to a significant increase in ATG9 and TBC1D5 co- localization with AP2 (Fig 5A-C), similar to the effect of starva- tion (Fig5D, Supplementary Fig S8A). This co-localization became even more pronounced when cells were pretreated with Dynasore and subsequently starved (Fig 5D, Supplementary Fig S8A).\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-u2os) taxid:9606(Homo sapiens U2OS osteosarcoma cell) |
| Parameters of the interaction | - |
| Creation date | 2014/10/06 |
| Update date | 2024/11/28 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | tandem tag:?-? |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Immunostaining |
| Participant identification method for interactor B | Anti tag immunostaining |