Curation Details
Interaction ID: IM-23178-1

Unique identifier for interactor Auniprotkb:Q14116
Unique identifier for interactor Buniprotkb:Q13478
Alternative identifier for interactor Aintact:EBI-3910835
uniprotkb:Q6FGY3
uniprotkb:O75599
uniprotkb:Q6WWJ7
intact:EBI-11016725
ensembl:ENSP00000280357.7
ensembl:ENSP00000434161.1
Alternative identifier for interactor Bintact:EBI-9817499
uniprotkb:B2R9Y5
uniprotkb:Q52LC9
ensembl:ENSP00000233957.1
ensembl:ENSP00000386663.1
ensembl:ENSP00000387211.1
Aliases for Apsi-mi:il18_human(display_long)
uniprotkb:IL18(gene name)
psi-mi:IL18(display_short)
uniprotkb:IGIF(gene name synonym)
uniprotkb:IL1F4(gene name synonym)
uniprotkb:Iboctadekin(gene name synonym)
uniprotkb:Interferon gamma-inducing factor(gene name synonym)
uniprotkb:Interleukin-1 gamma(gene name synonym)
Aliases for Bpsi-mi:il18r_human(display_long)
uniprotkb:Interleukin-18 receptor alpha(gene name synonym)
uniprotkb:IL18R1(gene name)
psi-mi:IL18R1(display_short)
uniprotkb:IL1RRP(gene name synonym)
uniprotkb:CD218 antigen-like family member A(gene name synonym)
uniprotkb:CDw218a(gene name synonym)
uniprotkb:IL1 receptor-related protein(gene name synonym)
Interaction detection methodspsi-mi:"MI:0114"(x-ray crystallography)
First authorWei et al. (2014)
Identifier of the publicationimex:IM-23178
pubmed:25261253
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-9817497
imex:IM-23178-1
Confidence scoreintact-miscore:0.56
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:t1 f1 f3 f4 sf2
comment:"\"The final model in the asymmetric unit contains two IL-18-IL-18Rα complexes (Figure S2A), with residues Tyr1-Asn155 in IL-18 and residues Ser21-Cys43, Thr51-Arg71, Arg75-Leu161, Pro169-GLu253, and Asn260-Asp318 in IL-18Rα.\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2014/09/16
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:37-193
Feature(s) for interactor Bbinding-associated region:19-329
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APredetermined participant
Participant identification method for interactor BPredetermined participant