Curation Details
Interaction ID: IM-23176-2

Unique identifier for interactor Auniprotkb:P0DP25
Unique identifier for interactor Buniprotkb:O35505
Alternative identifier for interactor Aintact:EBI-397435
uniprotkb:P0DP24
uniprotkb:P0DP23
uniprotkb:P62158
uniprotkb:P02593
uniprotkb:P70667
uniprotkb:P99014
uniprotkb:Q13942
uniprotkb:Q53S29
uniprotkb:Q61379
uniprotkb:Q61380
uniprotkb:Q96HK3
Alternative identifier for interactor Bintact:EBI-9084208
uniprotkb:Q9Z305
Aliases for Apsi-mi:calm_human(display_long)
uniprotkb:CALM1(gene name)
psi-mi:CALM1(display_short)
uniprotkb:CALM(gene name synonym)
uniprotkb:CAM(gene name synonym)
uniprotkb:CAM1(gene name synonym)
uniprotkb:CALM2(gene name)
psi-mi:CALM2(display_short)
uniprotkb:CAMB(gene name synonym)
uniprotkb:CALM3(gene name)
psi-mi:CALM3(display_short)
uniprotkb:CAM3(gene name synonym)
uniprotkb:CAMC(gene name synonym)
uniprotkb:CAMIII(gene name synonym)
uniprotkb:CAM2(gene name synonym)
uniprotkb:CALML2(gene name synonym)
Aliases for Bpsi-mi:cac1c_cavpo(display_long)
uniprotkb:CACNA1C(gene name)
psi-mi:CACNA1C(display_short)
uniprotkb:CACH2(gene name synonym)
uniprotkb:CACN2(gene name synonym)
uniprotkb:CACNL1A1(gene name synonym)
uniprotkb:CCHL1A1(gene name synonym)
uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)
uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)
Interaction detection methodspsi-mi:"MI:0096"(pull down)
First authorShao et al. (2014)
Identifier of the publicationimex:IM-23176
pubmed:25268113
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:10141(cavpo)
taxid:10141("Cavia porcellus (Guinea pig)")
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-9818917
imex:IM-23176-2
Confidence scoreintact-miscore:0.44
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f3 t1
comment:"\"To confirm that N-lobe may bind with CT1 at low Ca2+, we examined the binding of N-lobe12 with CT1. As shown in Fig. 3C, N-lobe12 bound to CT1 in a concentration-dependent manner but not in a Ca2+-dependent manner. The parameters obtained (Table 1) revealed that Kd values had no obvious Ca2+-dependence. The maximal binding was about 0.75 mol/mol N-lobe12/CT1 (Fig. 3D), supporting that N-lobe was capable to bind to the channel at low [Ca2+].\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2014/09/17
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:3-80
Feature(s) for interactor Bglutathione s tranferase tag:?-?
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AMolecular weight estimation by coomasie staining
Participant identification method for interactor BMolecular weight estimation by coomasie staining