Curation Details
Interaction ID: IM-23088-17

Unique identifier for interactor Auniprotkb:P20963
Unique identifier for interactor Buniprotkb:P29066
Alternative identifier for interactor Aintact:EBI-1165705
uniprotkb:B1AK49
ensembl:ENSP00000354782.5
uniprotkb:Q5VX13
uniprotkb:Q8TAX4
Alternative identifier for interactor Bintact:EBI-4303019
Aliases for Apsi-mi:cd3z_human(display_long)
uniprotkb:T-cell receptor T3 zeta chain(gene name synonym)
uniprotkb:CD247(gene name)
psi-mi:CD247(display_short)
uniprotkb:CD3Z(gene name synonym)
uniprotkb:T3Z(gene name synonym)
uniprotkb:TCRZ(gene name synonym)
Aliases for Bpsi-mi:arrb1_rat(display_long)
uniprotkb:Arrb1(gene name)
psi-mi:Arrb1(display_short)
uniprotkb:Arrestin beta-1(gene name synonym)
Interaction detection methodspsi-mi:"MI:0416"(fluorescence microscopy)
First authorFernández-Arenas et al. (2014)
Identifier of the publicationpubmed:24502978
imex:IM-23088
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:10116(rat)
taxid:10116("Rattus norvegicus (Rat)")
Interaction typespsi-mi:"MI:0403"(colocalization)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-9515155
imex:IM-23088-17
Confidence scoreintact-miscore:0.27
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f7d
comment:"\"We assessed the role of b-Arr1 in mediating CXCR4 translocation to the IS by analyzing Jurkat cells stimulated with superantigen- loaded APCs. In the presence of WT b-Arr1, CXCR4 localized with the TCR at the IS (Fig 7D), whereas expression of b-Arr1 (319- 418) induced the accumulation of both CXCR4 and the TCR in intracellular vesicles, preventing the accumulation of CXCR4 at the IS (Fig 7D).\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-jurkat)
taxid:9606(Homo sapiens Jurkat T-cell leukemia cell)
Parameters of the interaction-
Creation date2014/04/28
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Amcherry fluorescent protein tag:?-?
Feature(s) for interactor Bflag tag:?-?
binding-associated region:319-418
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor ATag visualisation by fluorescence
Participant identification method for interactor BAnti tag immunostaining