| Unique identifier for interactor A | uniprotkb:P43026 |
| Unique identifier for interactor B | uniprotkb:P43026 |
| Alternative identifier for interactor A | intact:EBI-8571476 uniprotkb:Q96SB1 intact:MINT-7264433 uniprotkb:E1P5Q2 ensembl:ENSP00000363489.3 ensembl:ENSP00000363492.1 |
| Alternative identifier for interactor B | intact:EBI-8571476 uniprotkb:Q96SB1 intact:MINT-7264433 uniprotkb:E1P5Q2 ensembl:ENSP00000363489.3 ensembl:ENSP00000363492.1 |
| Aliases for A | psi-mi:gdf5_human(display_long) uniprotkb:GDF5(gene name) psi-mi:GDF5(display_short) uniprotkb:CDMP1(gene name synonym) uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym) uniprotkb:Radotermin(gene name synonym) uniprotkb:BMP14(gene name synonym) uniprotkb:Bone morphogenetic protein 14(gene name synonym) uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym) |
| Aliases for B | psi-mi:gdf5_human(display_long) uniprotkb:GDF5(gene name) psi-mi:GDF5(display_short) uniprotkb:CDMP1(gene name synonym) uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym) uniprotkb:Radotermin(gene name synonym) uniprotkb:BMP14(gene name synonym) uniprotkb:Bone morphogenetic protein 14(gene name synonym) uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0107"(surface plasmon resonance) |
| First author | Thieme et al. (2014) |
| Identifier of the publication | imex:IM-23073 pubmed:25174448 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9693723 imex:IM-23073-2 |
| Confidence score | intact-miscore:0.44 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f7b comment:"\"part. In order to address this assumption via an independent experimental approach, the interaction of the proregion with the mature part was analyzed in SPR experiments. Mature GDF5 was immobilized and the proregion used as a soluble analyte. Association of the wild type proregion with mature GDF5 deviated from a 1 : 1 interaction. The curve shape was interpreted according to two binding reactions and one association constant with KD = 15.1 nM and the second one with KD = 911 nM. It is possible that the low affinity interaction reflects the association of the proregion with the mature part that has already bound one molecule of proregion. Association of GDF5 with the T201P proregion occurred at clearly reduced affinities of KD = 304 nM and KD = 7.2 μM.\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | kd:304.0x10^-9(molar) kd:7.2x10^-6(molar) |
| Creation date | 2014/08/25 |
| Update date | 2022/03/26 |
| negative Boolean value | false |
| Feature(s) for interactor A | mutation decreasing interaction:201-201 binding-associated region:28-381 |
| Feature(s) for interactor B | binding-associated region:382-501 |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Predetermined participant |
| Participant identification method for interactor B | Predetermined participant |