| Unique identifier for interactor A | uniprotkb:P27361 |
| Unique identifier for interactor B | uniprotkb:Q8N490 |
| Alternative identifier for interactor A | intact:EBI-73995 uniprotkb:B0LPG3 uniprotkb:A8CZ58 uniprotkb:Q8NHX1 ensembl:ENSP00000263025.4 |
| Alternative identifier for interactor B | intact:EBI-746368 uniprotkb:Q96A48 uniprotkb:Q9BU26 uniprotkb:Q9NSX4 uniprotkb:Q9ULN6 uniprotkb:Q9Y4T1 uniprotkb:A8K1F2 ensembl:ENSP00000273077.4 |
| Aliases for A | psi-mi:mk03_human(display_long) uniprotkb:ERT2(gene name synonym) uniprotkb:MAP kinase isoform p44(gene name synonym) uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym) uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym) uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym) uniprotkb:p44-ERK1(gene name synonym) uniprotkb:MAPK3(gene name) psi-mi:MAPK3(display_short) uniprotkb:ERK1(gene name synonym) uniprotkb:PRKM3(gene name synonym) |
| Aliases for B | psi-mi:pnkd_human(display_long) uniprotkb:Paroxysmal nonkinesiogenic dyskinesia protein(gene name synonym) uniprotkb:Myofibrillogenesis regulator 1(gene name synonym) uniprotkb:Trans-activated by hepatitis C virus core protein 2(gene name synonym) uniprotkb:PNKD(gene name) psi-mi:PNKD(display_short) uniprotkb:KIAA1184(gene name synonym) uniprotkb:MR1(gene name synonym) uniprotkb:TAHCCP2(gene name synonym) uniprotkb:FKSG19(orf name) uniprotkb:UNQ2491/PRO5778(orf name) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | Gong et al. (2014) |
| Identifier of the publication | imex:IM-23071 pubmed:25066297 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9663031 imex:IM-23071-2 |
| Confidence score | intact-miscore:0.56 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f4a comment:"\"To investigate whether MR-1 regulates MEK/ERK signaling through physical interaction, a co-immunoprecipitation (Co-IP) assay was performed between MR-1, MEK1/2 and ERK1/2 in MCF7 cells. Immunoprecipitation with an antibody recognizing MR-1 showed that MEK1/2 and ERK1 co-precipitated with MR-1 (Fig. 4A), but ERK2 did not. Immunoprecipitation of endogenous MEK1/2, ERK1 and ERK2 also showed that MR-1 was bound to MEK1/2 and ERK1, but not ERK2 (Fig. 4A).\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-mcf7) taxid:9606(Homo sapiens MCF-7 mammary adenocarcinoma cell) |
| Parameters of the interaction | - |
| Creation date | 2014/07/16 |
| Update date | 2024/09/12 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |