| Unique identifier for interactor A | uniprotkb:P58004 |
| Unique identifier for interactor B | uniprotkb:O70405 |
| Alternative identifier for interactor A | intact:EBI-3939642 uniprotkb:Q96SI5 uniprotkb:Q5T7D0 ensembl:ENSP00000253063.3 ensembl:ENSP00000496365.1 |
| Alternative identifier for interactor B | intact:EBI-8390771 intact:UNK-5365168 uniprotkb:Q6PGB2 |
| Aliases for A | psi-mi:sesn2_human(display_long) uniprotkb:SESN2(gene name) psi-mi:SESN2(display_short) uniprotkb:SEST2(gene name synonym) uniprotkb:Hi95(gene name synonym) uniprotkb:Hypoxia-induced gene(gene name synonym) |
| Aliases for B | psi-mi:ulk1_mouse(display_long) uniprotkb:Ulk1(gene name) psi-mi:Ulk1(display_short) uniprotkb:Unc-51-like kinase 1(gene name synonym) uniprotkb:Serine/threonine-protein kinase Unc51.1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0007"(anti tag coimmunoprecipitation) |
| First author | Ro et al. (2014) |
| Identifier of the publication | pubmed:25040165 imex:IM-23069 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:10090(mouse) taxid:10090(Mus musculus) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9638088 imex:IM-23069-1 |
| Confidence score | intact-miscore:0.58 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f1a f1b f2b comment:"\"we determined which subdomain of Sestrin2 is required for association with ULK1 and p62. Truncated Sestrin2 mutants lacking Sesn-B and Sesn-C domains (Sesn2HBC), Sesn-A domain (Sesn2HA) or Sesn-A and Sesn-B domains (Sesn2 HAB) were used in the protein binding assays. Sesn2HBC, Sesn2 HA and Sesn2 HAB, as well as the full-length form of Sestrin2 (Sesn2WT), were able to physically associate with ULK1 (Fig. 2B,C) and with p62 (Fig. 2D), suggesting that each of the subdomains of Sestrin2 can independently interact with ULK1 and p62\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293) taxid:9606(Homo sapiens HEK293 embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2014/07/03 |
| Update date | 2024/09/12 |
| negative Boolean value | false |
| Feature(s) for interactor A | flag tag:?-? |
| Feature(s) for interactor B | ha tag:?-? |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Anti tag western blot |
| Participant identification method for interactor B | Anti tag western blot |