| Unique identifier for interactor A | uniprotkb:Q02248 |
| Unique identifier for interactor B | uniprotkb:P70062 |
| Alternative identifier for interactor A | intact:EBI-397872 uniprotkb:Q922W1 uniprotkb:Q9D335 ensembl:ENSMUSP00000007130.9 ensembl:ENSMUSP00000136294.2 |
| Alternative identifier for interactor B | intact:EBI-6259044 |
| Aliases for A | psi-mi:ctnb1_mouse(display_long) uniprotkb:Beta-catenin(gene name synonym) uniprotkb:Ctnnb1(gene name) psi-mi:Ctnnb1(display_short) uniprotkb:Catnb(gene name synonym) |
| Aliases for B | psi-mi:t7l1a_xenla(display_long) uniprotkb:tcf7l1-a(gene name) psi-mi:tcf7l1-a(display_short) uniprotkb:tcf3(gene name synonym) uniprotkb:tcf3a(gene name synonym) uniprotkb:HMG box transcription factor 3-A(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0053"(fluorescence polarization spectroscopy) |
| First author | Chodaparambil et al. (2014) |
| Identifier of the publication | imex:IM-22946 pubmed:24596249 |
| NCBI Taxonomy identifier for interactor A | taxid:10090(mouse) taxid:10090(Mus musculus) |
| NCBI Taxonomy identifier for interactor B | taxid:8355(xenla) taxid:8355("Xenopus laevis (African clawed frog)") |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9547035 imex:IM-22946-7 |
| Confidence score | intact-miscore:0.40 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f3a comment:"\"Since the binding affinity is only 16 lM, we purified the b-catenin-TCF31–330 complex (KDs for b-catenin binding to the highly homologous LEF1 1–131 and TCF4 1–53 are 10 and 20 nM, respectively (Daniels and Weis, 2005; Fasolini et al, 2003; Sun and Weis, 2011)), and titrated increasing concentrations of this complex into labeled TLE120–156. The affinity of TLE120–156 for the b-catenin–TCF3 complex was 14 1 lM, essentially the same as the TLE120–156-TCF3 interaction (Fig 3A). These data demonstrate that there is no competition between b-catenin and TLE120–156 and, consistent with the domain mapping data (Table 1), that the binding regions for b-catenin and TLE120–156 on TCF3 are independent of one another.\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | kd:14.0x10^-6(molar) |
| Creation date | 2014/05/05 |
| Update date | 2024/09/12 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | binding-associated region:1-330 |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Predetermined participant |
| Participant identification method for interactor B | Predetermined participant |