| Unique identifier for interactor A | uniprotkb:P62805 |
| Unique identifier for interactor B | uniprotkb:Q04724 |
| Alternative identifier for interactor A | intact:EBI-302023 uniprotkb:A2VCL0 uniprotkb:P02304 uniprotkb:P02305 uniprotkb:Q6DRA9 uniprotkb:Q6FGB8 uniprotkb:Q6NWP7 ensembl:ENSP00000244537.6 ensembl:ENSP00000347168.2 ensembl:ENSP00000350767.3 ensembl:ENSP00000366956.1 ensembl:ENSP00000366974.2 ensembl:ENSP00000367034.3 ensembl:ENSP00000443017.1 ensembl:ENSP00000462355.1 ensembl:ENSP00000462667.1 ensembl:ENSP00000478519.1 ensembl:ENSP00000478786.1 ensembl:ENSP00000479106.2 ensembl:ENSP00000479461.2 ensembl:ENSP00000479794.2 ensembl:ENSP00000480960.2 ensembl:ENSP00000481343.1 ensembl:ENSP00000481486.1 ensembl:ENSP00000481507.1 ensembl:ENSP00000482412.1 ensembl:ENSP00000484789.1 ensembl:ENSP00000489319.1 ensembl:ENSP00000489567.1 |
| Alternative identifier for interactor B | intact:EBI-711424 ensembl:ENSP00000365682.3 uniprotkb:Q5T3G4 uniprotkb:Q969V9 uniprotkb:A8K495 |
| Aliases for A | psi-mi:h4_human(display_long) uniprotkb:H4C16(gene name) psi-mi:H4C16(display_short) uniprotkb:H4-16(gene name synonym) uniprotkb:H4C1(gene name) psi-mi:H4C1(display_short) uniprotkb:H4C11(gene name) psi-mi:H4C11(display_short) uniprotkb:H4C12(gene name) psi-mi:H4C12(display_short) uniprotkb:H4C13(gene name) psi-mi:H4C13(display_short) uniprotkb:H4C14(gene name) psi-mi:H4C14(display_short) uniprotkb:H4C15(gene name) psi-mi:H4C15(display_short) uniprotkb:H4C2(gene name) psi-mi:H4C2(display_short) uniprotkb:H4C3(gene name) psi-mi:H4C3(display_short) uniprotkb:H4C4(gene name) psi-mi:H4C4(display_short) uniprotkb:H4C5(gene name) psi-mi:H4C5(display_short) uniprotkb:H4C6(gene name) psi-mi:H4C6(display_short) uniprotkb:H4C8(gene name) psi-mi:H4C8(display_short) uniprotkb:H4C9(gene name) psi-mi:H4C9(display_short) uniprotkb:H4/A(gene name synonym) uniprotkb:H4/B(gene name synonym) uniprotkb:H4/C(gene name synonym) uniprotkb:H4/D(gene name synonym) uniprotkb:H4/E(gene name synonym) uniprotkb:H4/G(gene name synonym) uniprotkb:H4/H(gene name synonym) uniprotkb:H4/I(gene name synonym) uniprotkb:H4/J(gene name synonym) uniprotkb:H4/K(gene name synonym) uniprotkb:H4/M(gene name synonym) uniprotkb:H4/N(gene name synonym) uniprotkb:H4/O(gene name synonym) uniprotkb:H4F2(gene name synonym) uniprotkb:H4FA(gene name synonym) uniprotkb:H4FB(gene name synonym) uniprotkb:H4FC(gene name synonym) uniprotkb:H4FD(gene name synonym) uniprotkb:H4FE(gene name synonym) uniprotkb:H4FG(gene name synonym) uniprotkb:H4FH(gene name synonym) uniprotkb:H4FI(gene name synonym) uniprotkb:H4FJ(gene name synonym) uniprotkb:H4FK(gene name synonym) uniprotkb:H4FM(gene name synonym) uniprotkb:H4FN(gene name synonym) uniprotkb:H4FO(gene name synonym) uniprotkb:HIST1H4A(gene name synonym) uniprotkb:HIST1H4B(gene name synonym) uniprotkb:HIST1H4C(gene name synonym) uniprotkb:HIST1H4D(gene name synonym) uniprotkb:HIST1H4E(gene name synonym) uniprotkb:HIST1H4F(gene name synonym) uniprotkb:HIST1H4H(gene name synonym) uniprotkb:HIST1H4I(gene name synonym) uniprotkb:HIST1H4J(gene name synonym) uniprotkb:HIST1H4K(gene name synonym) uniprotkb:HIST1H4L(gene name synonym) uniprotkb:HIST2H4(gene name synonym) uniprotkb:HIST2H4A(gene name synonym) uniprotkb:HIST2H4B(gene name synonym) uniprotkb:HIST4H4(gene name synonym) |
| Aliases for B | psi-mi:tle1_human(display_long) uniprotkb:TLE1(gene name) psi-mi:TLE1(display_short) uniprotkb:Enhancer of split groucho-like protein 1(gene name synonym) uniprotkb:"E(Sp1) homolog"(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0047"(far western blotting) |
| First author | Chodaparambil et al. (2014) |
| Identifier of the publication | imex:IM-22946 pubmed:24596249 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9547658 imex:IM-22946-10 |
| Confidence score | intact-miscore:0.44 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f4d comment:"\"The binding of synthetic biotinylated histone tails to the TLE120–156 tetramer and dimer mutant was analyzed using native gel shifts to obtain relative binding affinities. The TLE120–156 tetramer bound to unmodified H4 and H4 trimethylated at lysine 20 (H4K20Me3; associated with heterochromatin) tails with apparent KDs of 42 and 13 lM, respectively (Fig 4C). The dimer also bound to these tails (Fig 4D). Binding to H2A, H2B and H3 was significantly weaker for both the tetramer and dimer (Fig 4C and D).\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | kd:37.0x10^-6(molar) |
| Creation date | 2014/05/05 |
| Update date | 2025/03/24 |
| negative Boolean value | false |
| Feature(s) for interactor A | binding-associated region:2-24 N6,N6,N6-trimethyl-L-lysine:20-20 |
| Feature(s) for interactor B | mutation decreasing interaction:26-26,29-29 binding-associated region:20-156 |
| Stoichiometry for interactor A | 1 |
| Stoichiometry for interactor B | 2 |
| Participant identification method for interactor A | Peptide synthesis |
| Participant identification method for interactor B | Predetermined participant |