| Unique identifier for interactor A | uniprotkb:P05067 |
| Unique identifier for interactor B | uniprotkb:P05067 |
| Alternative identifier for interactor A | intact:EBI-77613 uniprotkb:P09000 uniprotkb:P78438 uniprotkb:Q13764 uniprotkb:Q13778 uniprotkb:Q13793 intact:EBI-28985182 uniprotkb:Q6GSC0 uniprotkb:Q8WZ99 uniprotkb:Q9UC33 uniprotkb:Q9UCC8 uniprotkb:Q9UCD1 uniprotkb:Q9UQ58 uniprotkb:Q16011 uniprotkb:Q16014 uniprotkb:Q16019 uniprotkb:Q16020 uniprotkb:Q9BT38 uniprotkb:Q9UCA9 uniprotkb:Q9UCB6 uniprotkb:B4DII8 uniprotkb:B2R5V1 uniprotkb:D3DSD1 uniprotkb:D3DSD2 uniprotkb:D3DSD3 ensembl:ENSP00000284981.4 |
| Alternative identifier for interactor B | intact:EBI-77613 uniprotkb:P09000 uniprotkb:P78438 uniprotkb:Q13764 uniprotkb:Q13778 uniprotkb:Q13793 intact:EBI-28985182 uniprotkb:Q6GSC0 uniprotkb:Q8WZ99 uniprotkb:Q9UC33 uniprotkb:Q9UCC8 uniprotkb:Q9UCD1 uniprotkb:Q9UQ58 uniprotkb:Q16011 uniprotkb:Q16014 uniprotkb:Q16019 uniprotkb:Q16020 uniprotkb:Q9BT38 uniprotkb:Q9UCA9 uniprotkb:Q9UCB6 uniprotkb:B4DII8 uniprotkb:B2R5V1 uniprotkb:D3DSD1 uniprotkb:D3DSD2 uniprotkb:D3DSD3 ensembl:ENSP00000284981.4 |
| Aliases for A | psi-mi:a4_human(display_long) uniprotkb:APP(gene name) psi-mi:APP(display_short) uniprotkb:A4(gene name synonym) uniprotkb:AD1(gene name synonym) uniprotkb:Alzheimer disease amyloid protein(gene name synonym) uniprotkb:ABPP(gene name synonym) uniprotkb:PreA4(gene name synonym) uniprotkb:Cerebral vascular amyloid peptide(gene name synonym) uniprotkb:Protease nexin-II(gene name synonym) uniprotkb:APPI(gene name synonym) uniprotkb:Amyloid precursor protein(gene name synonym) uniprotkb:Amyloid-beta A4 protein(gene name synonym) uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym) uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym) |
| Aliases for B | psi-mi:a4_human(display_long) uniprotkb:APP(gene name) psi-mi:APP(display_short) uniprotkb:A4(gene name synonym) uniprotkb:AD1(gene name synonym) uniprotkb:Alzheimer disease amyloid protein(gene name synonym) uniprotkb:ABPP(gene name synonym) uniprotkb:PreA4(gene name synonym) uniprotkb:Cerebral vascular amyloid peptide(gene name synonym) uniprotkb:Protease nexin-II(gene name synonym) uniprotkb:APPI(gene name synonym) uniprotkb:Amyloid precursor protein(gene name synonym) uniprotkb:Amyloid-beta A4 protein(gene name synonym) uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym) uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0807"(comigration in gel electrophoresis) |
| First author | Zempel et al. (2013) |
| Identifier of the publication | pubmed:24065130 imex:IM-22943 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9099315 imex:IM-22943-9 |
| Confidence score | intact-miscore:0.99 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:sf1a sf1b comment:"\"Here, we employed a more potent preparation of AβOs that reflects the composition of Aβ in Alzheimer brain (70% Aβ40 and 30% Aβ42; Kuperstein et al, 2010, see Supplementary Results and Supplementary Figures S1 and S2). The preparation was composed of tri‐ and tetramers when analysed by SDS–PAGE, was positive for an oligomer‐specific antibody (A11 antibody by C Glabe: recognizes oligomers in a dot blot setting), and revealed aggregates of 5–25 nm size but no fibrils by negative stain electron microscopy (Supplementary Figure S1a–e).\"" comment:all preparations contain monomers and dimers, preparations containing Abeta 1-42 also contain tri- and tetramers. dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases. curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2014/01/27 |
| Update date | 2024/11/12 |
| negative Boolean value | false |
| Feature(s) for interactor A | binding-associated region:672-713 |
| Feature(s) for interactor B | binding-associated region:672-713 |
| Stoichiometry for interactor A | 3 |
| Stoichiometry for interactor B | 0 |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |