| Unique identifier for interactor A | uniprotkb:Q92844 |
| Unique identifier for interactor B | uniprotkb:Q969V5 |
| Alternative identifier for interactor A | intact:EBI-356349 uniprotkb:Q92885 uniprotkb:D3DPB5 uniprotkb:Q7Z4J6 ensembl:ENSP00000259075.2 ensembl:ENSP00000376505.2 |
| Alternative identifier for interactor B | intact:EBI-744120 uniprotkb:Q7Z431 uniprotkb:Q9H9B5 uniprotkb:B5M497 ensembl:ENSP00000264198.3 |
| Aliases for A | psi-mi:tank_human(display_long) uniprotkb:TANK(gene name) psi-mi:TANK(display_short) uniprotkb:ITRAF(gene name synonym) uniprotkb:TRAF2(gene name synonym) uniprotkb:TRAF-interacting protein(gene name synonym) |
| Aliases for B | psi-mi:mul1_human(display_long) uniprotkb:C1orf166(gene name synonym) uniprotkb:MAPL(gene name synonym) uniprotkb:MULAN(gene name synonym) uniprotkb:RNF218(gene name synonym) uniprotkb:E3 ubiquitin-protein ligase MUL1(gene name synonym) uniprotkb:GIDE(gene name synonym) uniprotkb:Mitochondrial-anchored protein ligase(gene name synonym) uniprotkb:RING finger protein 218(gene name synonym) uniprotkb:MUL1(gene name) psi-mi:MUL1(display_short) uniprotkb:Growth inhibition and death E3 ligase(gene name synonym) uniprotkb:Putative NF-kappa-B-activating protein 266(gene name synonym) uniprotkb:E3 SUMO-protein ligase MUL1(gene name synonym) uniprotkb:RING-type E3 ubiquitin transferase NFKB 1(gene name synonym) uniprotkb:Protein Hades(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | Zemirli et al. (2014) |
| Identifier of the publication | pubmed:24841215 imex:IM-22598 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9524945 imex:IM-22598-1 |
| Confidence score | intact-miscore:0.40 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f7a comment:"\"As TRAF2 was found to be required for the activation of NF-κB by MULAN (Fig. 2E), we hypothesized that these two E3 ubiquitin ligases are part of the same complex, promoting NF- κB activation, during SIMH. We then immunoprecipitated TRAF2 and demonstrated a timedependent recruitment of MULAN after the induction of SIMH (Fig. 7A) suggesting that these two proteins integrate the same complex after SIMH induction. When OPA1 expression was knocked down to suppress SIMH, the association between TRAF2 and MULAN was impaired (Fig. 7B), indicating a requirement for mitochondrial network fusion for the formation of a TRAF2-MULAN complex to ensure NF-κB activation.\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293t) taxid:9606(Homo sapiens HEK293T embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2014/05/14 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |