| Unique identifier for interactor A | uniprotkb:P04626 |
| Unique identifier for interactor B | uniprotkb:P06241 |
| Alternative identifier for interactor A | intact:EBI-641062 uniprotkb:B2RZG3 uniprotkb:B4DHN3 uniprotkb:X5D2V5 ensembl:ENSP00000269571.4 uniprotkb:Q14256 uniprotkb:Q6LDV1 uniprotkb:Q9UMK4 |
| Alternative identifier for interactor B | intact:EBI-515315 uniprotkb:B5BU57 intact:EBI-2561531 uniprotkb:E1P557 uniprotkb:H0UI48 ensembl:ENSP00000346671.3 ensembl:ENSP00000357656.2 uniprotkb:Q16248 uniprotkb:Q5R3A6 uniprotkb:Q5R3A7 uniprotkb:Q8N5D7 |
| Aliases for A | psi-mi:erbb2_human(display_long) uniprotkb:p185erbB2(gene name synonym) uniprotkb:MLN19(gene name synonym) uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym) uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym) uniprotkb:Proto-oncogene Neu(gene name synonym) uniprotkb:ERBB2(gene name) psi-mi:ERBB2(display_short) uniprotkb:HER2(gene name synonym) uniprotkb:NEU(gene name synonym) uniprotkb:NGL(gene name synonym) uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) |
| Aliases for B | psi-mi:fyn_human(display_long) uniprotkb:p59-Fyn(gene name synonym) uniprotkb:Proto-oncogene c-Fyn(gene name synonym) uniprotkb:Src-like kinase(gene name synonym) uniprotkb:FYN(gene name) psi-mi:FYN(display_short) uniprotkb:Proto-oncogene Syn(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0077"(nuclear magnetic resonance) |
| First author | Bornet et al. (2014) |
| Identifier of the publication | imex:IM-22589 pubmed:24815698 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9396596 imex:IM-22589-1 |
| Confidence score | intact-miscore:0.56 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f1 f2a f5a comment:"\"we performed a NMR titration of Fyn-SH3/ R1P2Q3P4P5S6P7R8E9 peptide interactions. 15N-HSQC of Fyn-SH3 domain recorded in the presence of the ErbB2 peptide, revealed that this peptide induced chemical shifts on some NH correlation peaks of Fyn-SH3 (Figure 1A). The fast exchange observed between the free and bound forms were in agreement with a KD of 0.935 mM as determined by NMR and of 0.909 mM as determined by surface plasmon resonance experiments (Figure 2).\"" comment:"\"NMR titration performed with this mutant indicated that residues P2, P5 and R8 were not essential for the interaction of the peptide with Fyn-SH3 (Figure 1C).\"" comment:"\"NMR titration experiments revealed that these three residues are essential for the interaction since their substitution abolished the complex formation with Fyn SH3 (Figure 1B).\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2014/04/23 |
| Update date | 2014/10/16 |
| negative Boolean value | false |
| Feature(s) for interactor A | mutation disrupting interaction:1146-1146,1149-1149,1152-1152 binding-associated region:1146-1154 |
| Feature(s) for interactor B | binding-associated region:82-143 |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Peptide synthesis |
| Participant identification method for interactor B | Predetermined participant |