| Unique identifier for interactor A | uniprotkb:P05067 |
| Unique identifier for interactor B | uniprotkb:P05067 |
| Alternative identifier for interactor A | intact:EBI-77613 uniprotkb:P09000 uniprotkb:P78438 uniprotkb:Q13764 uniprotkb:Q13778 uniprotkb:Q13793 intact:EBI-28985182 uniprotkb:Q6GSC0 uniprotkb:Q8WZ99 uniprotkb:Q9UC33 uniprotkb:Q9UCC8 uniprotkb:Q9UCD1 uniprotkb:Q9UQ58 uniprotkb:Q16011 uniprotkb:Q16014 uniprotkb:Q16019 uniprotkb:Q16020 uniprotkb:Q9BT38 uniprotkb:Q9UCA9 uniprotkb:Q9UCB6 uniprotkb:B4DII8 uniprotkb:B2R5V1 uniprotkb:D3DSD1 uniprotkb:D3DSD2 uniprotkb:D3DSD3 ensembl:ENSP00000284981.4 |
| Alternative identifier for interactor B | intact:EBI-77613 uniprotkb:P09000 uniprotkb:P78438 uniprotkb:Q13764 uniprotkb:Q13778 uniprotkb:Q13793 intact:EBI-28985182 uniprotkb:Q6GSC0 uniprotkb:Q8WZ99 uniprotkb:Q9UC33 uniprotkb:Q9UCC8 uniprotkb:Q9UCD1 uniprotkb:Q9UQ58 uniprotkb:Q16011 uniprotkb:Q16014 uniprotkb:Q16019 uniprotkb:Q16020 uniprotkb:Q9BT38 uniprotkb:Q9UCA9 uniprotkb:Q9UCB6 uniprotkb:B4DII8 uniprotkb:B2R5V1 uniprotkb:D3DSD1 uniprotkb:D3DSD2 uniprotkb:D3DSD3 ensembl:ENSP00000284981.4 |
| Aliases for A | psi-mi:a4_human(display_long) uniprotkb:APP(gene name) psi-mi:APP(display_short) uniprotkb:A4(gene name synonym) uniprotkb:AD1(gene name synonym) uniprotkb:Alzheimer disease amyloid protein(gene name synonym) uniprotkb:ABPP(gene name synonym) uniprotkb:PreA4(gene name synonym) uniprotkb:Cerebral vascular amyloid peptide(gene name synonym) uniprotkb:Protease nexin-II(gene name synonym) uniprotkb:APPI(gene name synonym) uniprotkb:Amyloid precursor protein(gene name synonym) uniprotkb:Amyloid-beta A4 protein(gene name synonym) uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym) uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym) |
| Aliases for B | psi-mi:a4_human(display_long) uniprotkb:APP(gene name) psi-mi:APP(display_short) uniprotkb:A4(gene name synonym) uniprotkb:AD1(gene name synonym) uniprotkb:Alzheimer disease amyloid protein(gene name synonym) uniprotkb:ABPP(gene name synonym) uniprotkb:PreA4(gene name synonym) uniprotkb:Cerebral vascular amyloid peptide(gene name synonym) uniprotkb:Protease nexin-II(gene name synonym) uniprotkb:APPI(gene name synonym) uniprotkb:Amyloid precursor protein(gene name synonym) uniprotkb:Amyloid-beta A4 protein(gene name synonym) uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym) uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0049"(filter binding) |
| First author | Chang et al. (2014) |
| Identifier of the publication | imex:IM-22567 pubmed:24720730 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9353041 imex:IM-22567-6 |
| Confidence score | intact-miscore:0.99 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f1b comment:"\"To investigate conformational changes of Aβ species during the aggregation, we used dot blot analysis probed by different Aβ antibodies to detect their epitope changes. Different time points at 0, 6, 13, 29, 49, 74, and 135 hr of incubation were dotted with several replicates. The antibodies used were the conformation-dependent antibody A11 that recognizes common amyloid prefibrillar oligomers [33], and OC that recognizes fibrils and fibrillar oligomers, which are a kind of amyloid oligomers that are immunologically and structurally related to fibrils [34, 35] (Figure 1b).\"" dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2014/04/04 |
| Update date | 2024/11/12 |
| negative Boolean value | false |
| Feature(s) for interactor A | binding-associated region:672-711 |
| Feature(s) for interactor B | binding-associated region:672-711 |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Identification by antibody |
| Participant identification method for interactor B | Identification by antibody |