Curation Details
Interaction ID: IM-22567-13

Unique identifier for interactor Auniprotkb:P05067
Unique identifier for interactor Buniprotkb:P05067
Alternative identifier for interactor Aintact:EBI-77613
uniprotkb:B4DII8
uniprotkb:B2R5V1
uniprotkb:D3DSD1
uniprotkb:D3DSD2
uniprotkb:D3DSD3
ensembl:ENSP00000284981.4
uniprotkb:P09000
uniprotkb:P78438
uniprotkb:Q13764
uniprotkb:Q13778
uniprotkb:Q13793
intact:EBI-28985182
uniprotkb:Q6GSC0
uniprotkb:Q8WZ99
uniprotkb:Q9UC33
uniprotkb:Q9UCC8
uniprotkb:Q9UCD1
uniprotkb:Q9UQ58
uniprotkb:Q16011
uniprotkb:Q16014
uniprotkb:Q16019
uniprotkb:Q16020
uniprotkb:Q9BT38
uniprotkb:Q9UCA9
uniprotkb:Q9UCB6
Alternative identifier for interactor Bintact:EBI-77613
uniprotkb:B4DII8
uniprotkb:B2R5V1
uniprotkb:D3DSD1
uniprotkb:D3DSD2
uniprotkb:D3DSD3
ensembl:ENSP00000284981.4
uniprotkb:P09000
uniprotkb:P78438
uniprotkb:Q13764
uniprotkb:Q13778
uniprotkb:Q13793
intact:EBI-28985182
uniprotkb:Q6GSC0
uniprotkb:Q8WZ99
uniprotkb:Q9UC33
uniprotkb:Q9UCC8
uniprotkb:Q9UCD1
uniprotkb:Q9UQ58
uniprotkb:Q16011
uniprotkb:Q16014
uniprotkb:Q16019
uniprotkb:Q16020
uniprotkb:Q9BT38
uniprotkb:Q9UCA9
uniprotkb:Q9UCB6
Aliases for Apsi-mi:a4_human(display_long)
uniprotkb:APP(gene name)
psi-mi:APP(display_short)
uniprotkb:A4(gene name synonym)
uniprotkb:AD1(gene name synonym)
uniprotkb:Alzheimer disease amyloid protein(gene name synonym)
uniprotkb:ABPP(gene name synonym)
uniprotkb:PreA4(gene name synonym)
uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)
uniprotkb:Protease nexin-II(gene name synonym)
uniprotkb:APPI(gene name synonym)
uniprotkb:Amyloid precursor protein(gene name synonym)
uniprotkb:Amyloid-beta A4 protein(gene name synonym)
uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)
uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)
Aliases for Bpsi-mi:a4_human(display_long)
uniprotkb:APP(gene name)
psi-mi:APP(display_short)
uniprotkb:A4(gene name synonym)
uniprotkb:AD1(gene name synonym)
uniprotkb:Alzheimer disease amyloid protein(gene name synonym)
uniprotkb:ABPP(gene name synonym)
uniprotkb:PreA4(gene name synonym)
uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)
uniprotkb:Protease nexin-II(gene name synonym)
uniprotkb:APPI(gene name synonym)
uniprotkb:Amyloid precursor protein(gene name synonym)
uniprotkb:Amyloid-beta A4 protein(gene name synonym)
uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)
uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)
Interaction detection methodspsi-mi:"MI:0030"(cross-linking study)
First authorChang et al. (2014)
Identifier of the publicationimex:IM-22567
pubmed:24720730
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-9353169
imex:IM-22567-13
Confidence scoreintact-miscore:0.99
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f4
comment:"\"To characterize the oligomer assembly, we used Western blot analysis to examine the Aβ mixing ratios (Figure 4). We collected the time points at 0, 6, 80, and 104 hr incubation (Figure 4a) based on the fact that the oligomer peak of Aβ42 alone in SEC showed significant decrease after 104 hr. To avoid SDS denaturation of the Aβ assembly, we also adopted the PICUP assay [37] to cross-link the assemblies before performing western blotting (Figure 4b).\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2014/04/04
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:672-713
Feature(s) for interactor Bbinding-associated region:672-711
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot