Curation Details
Interaction ID: IM-22555-1

Unique identifier for interactor Auniprotkb:Q61169
Unique identifier for interactor Buniprotkb:P46152
Alternative identifier for interactor Aintact:EBI-8065049
ensembl:ENSMUSP00000041774.8
uniprotkb:Q9QZK3
intact:MINT-1782188
uniprotkb:Q3UQJ2
uniprotkb:P97729
Alternative identifier for interactor Bintact:EBI-9257939
ensembl:ENSRNOP00000014320.3
ensembl:ENSRNOP00055016215
ensembl:ENSRNOP00060027589
ensembl:ENSRNOP00065041280
Aliases for Apsi-mi:gata6_mouse(display_long)
uniprotkb:Gata6(gene name)
psi-mi:Gata6(display_short)
uniprotkb:GATA-binding factor 6(gene name synonym)
Aliases for Bpsi-mi:gata4_rat(display_long)
uniprotkb:Gata4(gene name)
psi-mi:Gata4(display_short)
uniprotkb:DNA-binding protein GATA-GT2(gene name synonym)
uniprotkb:GATA-binding factor 4(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorKee et al. (2014)
Identifier of the publicationpubmed:24662306
imex:IM-22555
NCBI Taxonomy identifier for interactor Ataxid:10090(mouse)
taxid:10090(Mus musculus)
NCBI Taxonomy identifier for interactor Btaxid:10116(rat)
taxid:10116("Rattus norvegicus (Rat)")
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-9255098
imex:IM-22555-1
Confidence scoreintact-miscore:0.40
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f4e f4f
comment:"\"We further investigated whether the potentiation of GATA4/GATA6-mediated transactivation of the ANP promoter was attributable to binding of GATA4 to GATA6. Immunoprecipitation revealed that GATA4 physically interacted with GATA6 in 293T cells 11 (Fig. 4E). Treatment of piceatannol in 293T cells co-transfected with GATA4 and GATA6 reduced the interaction between GATA4 and GATA6 (Fig. 4F).\""
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:9606(human-293t)
taxid:9606(Homo sapiens HEK293T embryonic kidney cell)
Parameters of the interaction-
Creation date2014/03/10
Update date2024/09/12
negative Boolean valuefalse
Feature(s) for interactor Av5 tag:?-?
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AAnti tag western blot
Participant identification method for interactor BWestern blot