| Unique identifier for interactor A | uniprotkb:Q86WX3 |
| Unique identifier for interactor B | uniprotkb:Q96EB6 |
| Alternative identifier for interactor A | intact:EBI-4479407 ensembl:ENSP00000333948.3 uniprotkb:B0QY96 uniprotkb:Q5JZA1 |
| Alternative identifier for interactor B | intact:EBI-1802965 ensembl:ENSP00000212015.6 uniprotkb:Q2XNF6 uniprotkb:Q5JVQ0 uniprotkb:Q9GZR9 uniprotkb:Q9Y6F0 |
| Aliases for A | psi-mi:aros_human(display_long) uniprotkb:RPS19BP1(gene name) psi-mi:RPS19BP1(display_short) uniprotkb:AROS(gene name synonym) uniprotkb:40S ribosomal protein S19-binding protein 1(gene name synonym) |
| Aliases for B | psi-mi:sir1_human(display_long) uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym) uniprotkb:SIRT1(gene name) psi-mi:SIRT1(display_short) uniprotkb:SIR2L1(gene name synonym) uniprotkb:SIR2-like protein 1(gene name synonym) uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | Kokkola et al. (2014) |
| Identifier of the publication | imex:IM-22550 pubmed:24681097 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9255015 imex:IM-22550-1 |
| Confidence score | intact-miscore:0.73 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f1 f2 sf2 comment:"\"The design and construction of SIRT1 truncation mutants did not provide specific answer to determine the exact region for the SIRT1/AROS interaction, since the truncated forms of SIRT1 failed to co-immunoprecipitate with AROS (Fig. 2).\"" comment:"\"The AROS peptides (AR1-5) were found to exert an inhibitory effect on SIRT1 activity in two different in vitro assays (Supplementary Table 2), although a molar excess of the peptides was not able to block the interaction between SIRT1 and AROS in co-immunoprecipitation analyses (Supplementary Fig. 2)\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293t) taxid:9606(Homo sapiens HEK293T embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2014/03/10 |
| Update date | 2014/10/16 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |