Curation Details
Interaction ID: IM-22546-1

Unique identifier for interactor Auniprotkb:Q16832
Unique identifier for interactor Buniprotkb:Q13191
Alternative identifier for interactor Aintact:EBI-1381484
uniprotkb:Q7Z730
ensembl:ENSP00000356898.3
ensembl:ENSP00000356899.2
ensembl:ENSP00000400309.2
Alternative identifier for interactor Bintact:EBI-744027
uniprotkb:Q63Z43
uniprotkb:A8K9S7
uniprotkb:Q13192
uniprotkb:Q13193
uniprotkb:Q3LIC0
uniprotkb:Q8IVC5
uniprotkb:B7WNM4
intact:EBI-28969458
ensembl:ENSP00000377598.4
intact:EBI-8051403
intact:MINT-7907019
Aliases for Apsi-mi:ddr2_human(display_long)
uniprotkb:Discoidin domain-containing receptor tyrosine kinase 2(gene name synonym)
uniprotkb:DDR2(gene name)
psi-mi:DDR2(display_short)
uniprotkb:NTRKR3(gene name synonym)
uniprotkb:TKT(gene name synonym)
uniprotkb:TYRO10(gene name synonym)
uniprotkb:Receptor protein-tyrosine kinase TKT(gene name synonym)
uniprotkb:Tyrosine-protein kinase TYRO10(gene name synonym)
uniprotkb:Neurotrophic tyrosine kinase, receptor-related 3(gene name synonym)
uniprotkb:CD167 antigen-like family member B(gene name synonym)
Aliases for Bpsi-mi:cblb_human(display_long)
uniprotkb:Signal transduction protein CBL-B(gene name synonym)
uniprotkb:SH3-binding protein CBL-B(gene name synonym)
uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)
uniprotkb:RING finger protein 56(gene name synonym)
uniprotkb:CBLB(gene name)
psi-mi:CBLB(display_short)
uniprotkb:RNF56(gene name synonym)
uniprotkb:Nbla00127(orf name)
uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorYu et al. (2014)
Identifier of the publicationpubmed:24631539
imex:IM-22546
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-9250382
imex:IM-22546-1
Confidence scoreintact-miscore:0.40
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F1C
comment:As shown in Fig. 1C, Cbl-b could be detected in anti-Myc immunoprecipitates from collagen II-treated cells but not in those from un-stimulated cells. Thus, upon activation, DDR2 can form complex with Cbl-b.
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:9606(human-293t)
taxid:9606(Homo sapiens HEK293T embryonic kidney cell)
Parameters of the interaction-
Creation date2014/03/03
Update date2024/11/30
negative Boolean valuefalse
Feature(s) for interactor Amyc tag:?-?
Feature(s) for interactor Bxpress tag:?-?
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AAnti tag western blot
Participant identification method for interactor BAnti tag western blot