| Unique identifier for interactor A | uniprotkb:P56817 |
| Unique identifier for interactor B | uniprotkb:Q14254 |
| Alternative identifier for interactor A | intact:EBI-2433139 ensembl:ENSP00000318585.6 uniprotkb:B0YIU9 uniprotkb:Q9BYB9 uniprotkb:Q9BYC0 uniprotkb:Q9BYC1 uniprotkb:Q9UJT5 uniprotkb:Q9ULS1 uniprotkb:E9PE65 uniprotkb:H7BXJ9 uniprotkb:A0M8W7 |
| Alternative identifier for interactor B | intact:EBI-348613 ensembl:ENSP00000378368.3 |
| Aliases for A | psi-mi:bace1_human(display_long) uniprotkb:BACE(gene name synonym) uniprotkb:KIAA1149(gene name synonym) uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym) uniprotkb:Membrane-associated aspartic protease 2(gene name synonym) uniprotkb:Memapsin-2(gene name synonym) uniprotkb:Aspartyl protease 2(gene name synonym) uniprotkb:BACE1(gene name) psi-mi:BACE1(display_short) |
| Aliases for B | psi-mi:flot2_human(display_long) uniprotkb:FLOT2(gene name) psi-mi:FLOT2(display_short) uniprotkb:ESA1(gene name synonym) uniprotkb:M17S1(gene name synonym) uniprotkb:Epidermal surface antigen(gene name synonym) uniprotkb:Membrane component chromosome 17 surface marker 1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | John et al. (2014) |
| Identifier of the publication | pubmed:24612608 imex:IM-22281 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0914"(association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9213800 imex:IM-22281-2 |
| Confidence score | intact-miscore:0.42 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f2a comment:"\"To corroborate these findings in an in vivo context, we performed coimmunoprecipitation experiments with endogenous flotillins and BACE1 (Figure 2A). For this, we used polyclonal flotillin-2 antibodies since they result in a quantitative precipitation of the pool of flotillin-1/flotillin-2 complexes in the cells. BACE1 was found to be immunoprecipitated with endogenous flotillin-2, verifying the relevance of the pulldown data.\"" dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-hela) taxid:9606(Homo sapiens HeLa epitheloid cervical carcinoma cell) |
| Parameters of the interaction | - |
| Creation date | 2014/02/21 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |