| Unique identifier for interactor A | uniprotkb:P04637 |
| Unique identifier for interactor B | uniprotkb:P17844 |
| Alternative identifier for interactor A | intact:EBI-366083 uniprotkb:Q15086 uniprotkb:Q15087 uniprotkb:Q15088 uniprotkb:Q16535 uniprotkb:Q16807 uniprotkb:Q16808 uniprotkb:Q16809 uniprotkb:Q16810 uniprotkb:Q16811 uniprotkb:Q16848 uniprotkb:Q86UG1 uniprotkb:Q8J016 uniprotkb:Q99659 uniprotkb:Q9BTM4 uniprotkb:Q9HAQ8 uniprotkb:Q9NP68 uniprotkb:Q9NPJ2 uniprotkb:Q9NZD0 uniprotkb:Q9UBI2 uniprotkb:Q9UQ61 intact:EBI-28980681 ensembl:ENSP00000269305.4 ensembl:ENSP00000391478.2 ensembl:ENSP00000424104.2 ensembl:ENSP00000426252.2 uniprotkb:Q2XN98 uniprotkb:Q3LRW1 uniprotkb:Q3LRW2 uniprotkb:Q3LRW3 uniprotkb:Q3LRW4 uniprotkb:Q3LRW5 |
| Alternative identifier for interactor B | intact:EBI-351962 uniprotkb:O75681 uniprotkb:Q53Y61 uniprotkb:B4DLW8 uniprotkb:E7ETL9 uniprotkb:B5BU21 uniprotkb:D3DU32 ensembl:ENSP00000225792.5 ensembl:ENSP00000403085.3 ensembl:ENSP00000463168.2 ensembl:ENSP00000464337.2 ensembl:ENSP00000504794.1 |
| Aliases for A | psi-mi:p53_human(display_long) uniprotkb:TP53(gene name) psi-mi:TP53(display_short) uniprotkb:P53(gene name synonym) uniprotkb:Tumor suppressor p53(gene name synonym) uniprotkb:Phosphoprotein p53(gene name synonym) uniprotkb:Antigen NY-CO-13(gene name synonym) |
| Aliases for B | psi-mi:ddx5_human(display_long) uniprotkb:HLR1(gene name synonym) uniprotkb:DDX5(gene name) psi-mi:DDX5(display_short) uniprotkb:HELR(gene name synonym) uniprotkb:G17P1(gene name synonym) uniprotkb:DEAD box protein 5(gene name synonym) uniprotkb:RNA helicase p68(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | Chang et al. (2013) |
| Identifier of the publication | imex:IM-22245 pubmed:24219989 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9086612 imex:IM-22245-2 |
| Confidence score | intact-miscore:0.66 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | comment:"\"The acetyl‐K120 mimic K120Q was constitutively associated with p68 and Drosha in the absence of CPT treatment (Figure 6B), while WT p53 associated with p68 upon DNA damage stress (Figure 6A), suggesting that K120 acetylation is sufficient to promote interaction of p53 with the Drosha complex. K120R mutant of p53 was unable to interact with p68 both in the presence and absence of CPT stimulation (Figure 6B; Supplementary Figure S8).\"" figure legend:sf8 curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-hct116) taxid:9606(Homo sapiens HCT116 colon carcinoma cell) |
| Parameters of the interaction | - |
| Creation date | 2014/01/16 |
| Update date | 2024/09/12 |
| negative Boolean value | false |
| Feature(s) for interactor A | mutation disrupting interaction:120-120 |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |