| Unique identifier for interactor A | uniprotkb:P04637 |
| Unique identifier for interactor B | uniprotkb:P17844 |
| Alternative identifier for interactor A | intact:EBI-366083 uniprotkb:Q2XN98 uniprotkb:Q3LRW1 uniprotkb:Q3LRW2 uniprotkb:Q3LRW3 uniprotkb:Q3LRW4 uniprotkb:Q3LRW5 uniprotkb:Q15086 uniprotkb:Q15087 uniprotkb:Q15088 uniprotkb:Q16535 uniprotkb:Q16807 uniprotkb:Q16808 uniprotkb:Q16809 uniprotkb:Q16810 uniprotkb:Q16811 uniprotkb:Q16848 uniprotkb:Q86UG1 uniprotkb:Q8J016 uniprotkb:Q99659 uniprotkb:Q9BTM4 uniprotkb:Q9HAQ8 uniprotkb:Q9NP68 uniprotkb:Q9NPJ2 uniprotkb:Q9NZD0 uniprotkb:Q9UBI2 uniprotkb:Q9UQ61 ensembl:ENSP00000269305.4 ensembl:ENSP00000391478.2 ensembl:ENSP00000424104.2 ensembl:ENSP00000426252.2 intact:EBI-28980681 |
| Alternative identifier for interactor B | intact:EBI-351962 uniprotkb:B5BU21 uniprotkb:D3DU32 ensembl:ENSP00000225792.5 ensembl:ENSP00000403085.3 ensembl:ENSP00000463168.2 ensembl:ENSP00000464337.2 ensembl:ENSP00000504794.1 uniprotkb:O75681 uniprotkb:Q53Y61 uniprotkb:B4DLW8 uniprotkb:E7ETL9 |
| Aliases for A | psi-mi:p53_human(display_long) uniprotkb:TP53(gene name) psi-mi:TP53(display_short) uniprotkb:P53(gene name synonym) uniprotkb:Tumor suppressor p53(gene name synonym) uniprotkb:Phosphoprotein p53(gene name synonym) uniprotkb:Antigen NY-CO-13(gene name synonym) |
| Aliases for B | psi-mi:ddx5_human(display_long) uniprotkb:HLR1(gene name synonym) uniprotkb:DDX5(gene name) psi-mi:DDX5(display_short) uniprotkb:HELR(gene name synonym) uniprotkb:G17P1(gene name synonym) uniprotkb:DEAD box protein 5(gene name synonym) uniprotkb:RNA helicase p68(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | Chang et al. (2013) |
| Identifier of the publication | imex:IM-22245 pubmed:24219989 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9086602 imex:IM-22245-1 |
| Confidence score | intact-miscore:0.66 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | comment:"\"We tested whether K120 acetylation of p53 stabilizes the interaction with p68, in turn promoting p53‐dependent pri‐miRNA processing. p68 was immunoprecipitated from nuclear extracts of cells stimulated with CPT or Nut3, followed by immunoblot analysis using antibodies against total p53 or K120‐acetylated p53 (p53‐Ac‐K120) (Figure 6A). Although levels of total p53 and K382‐acetylated p53 were similar following both CPT and Nut3 treatment, only CPT increased K120 acetylation (Figure 6A, input) and the interaction between p53 and p68 (Figure 6A, IP: p68). We also confirmed that the p53 associated with p68 upon CPT treatment was K120 acetylated (Figure 6A, p53‐Ac‐K120). Lysine acetylation of p68 was not detected following CPT or Nut3 treatment (Figure 6A, Ac‐p68).\"" figure legend:f6a full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-hct116) taxid:9606(Homo sapiens HCT116 colon carcinoma cell) |
| Parameters of the interaction | - |
| Creation date | 2014/01/16 |
| Update date | 2014/10/16 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |