Curation Details
Interaction ID: IM-22217-3

Unique identifier for interactor Auniprotkb:Q15154
Unique identifier for interactor Buniprotkb:Q9Y2D8
Alternative identifier for interactor Aintact:EBI-741421
intact:EBI-2563316
intact:EBI-16421643
intact:EBI-10961691
ensembl:ENSP00000327077.8
uniprotkb:A6NNN6
uniprotkb:B4DYD5
uniprotkb:E7ETA6
uniprotkb:E7EV56
uniprotkb:Q58F13
uniprotkb:Q6P1K7
uniprotkb:Q8NB85
uniprotkb:Q9BWC1
uniprotkb:Q9H4A2
Alternative identifier for interactor Bintact:EBI-2212028
uniprotkb:D3DT13
uniprotkb:Q6P2P8
uniprotkb:Q6ULS1
uniprotkb:Q7L168
uniprotkb:Q9UIX0
intact:EBI-10964529
ensembl:ENSP00000340279.3
uniprotkb:B4DFE3
uniprotkb:J3KR02
uniprotkb:A8K8W0
Aliases for Apsi-mi:pcm1_human(display_long)
uniprotkb:PCM1(gene name)
psi-mi:PCM1(display_short)
Aliases for Bpsi-mi:adip_human(display_long)
uniprotkb:SSX2IP(gene name)
psi-mi:SSX2IP(display_short)
uniprotkb:KIAA0923(gene name synonym)
uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)
uniprotkb:SSX2-interacting protein(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorHori et al. (2014)
Identifier of the publicationimex:IM-22217
pubmed:24397932
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0914"(association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-9214110
imex:IM-22217-3
Confidence scoreintact-miscore:0.61
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:sf1h sf3b
comment:Note that hMsd1 binds to γ-tubulin during the whole cell cycle, whilst binding to PCM1 is not detected during mitosis. hMsd1 appears to interact with Plk1 in a mitosis specific manner, the mechanism of which remains to be addressed.
comment:"\"On the other hand, the hMsd1 mutant lacking the C-terminal half (hMsd1-N, 1– 373 aa) was capable of interacting with PCM1, but not c-tubulin (Fig 3A and supplementary Fig S3).\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-hela)
taxid:9606(Homo sapiens HeLa epitheloid cervical carcinoma cell)
Parameters of the interaction-
Creation date2014/02/24
Update date2024/01/26
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor Bbinding-associated region:1-373
green fluorescent protein tag:?-?
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BAnti tag western blot