| Unique identifier for interactor A | uniprotkb:Q99963 |
| Unique identifier for interactor B | uniprotkb:Q70E73 |
| Alternative identifier for interactor A | intact:EBI-473910 ensembl:ENSP00000391372.2 ensembl:ENSP00000517113.1 uniprotkb:O43553 uniprotkb:O43554 |
| Alternative identifier for interactor B | intact:EBI-3940924 uniprotkb:Q9C0I2 uniprotkb:Q96Q37 ensembl:ENSP00000316543.5 |
| Aliases for A | psi-mi:sh3g3_human(display_long) uniprotkb:Endophilin-3(gene name synonym) uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym) uniprotkb:SH3 domain protein 2C(gene name synonym) uniprotkb:EEN-B2(gene name synonym) uniprotkb:SH3GL3(gene name) psi-mi:SH3GL3(display_short) uniprotkb:CNSA3(gene name synonym) uniprotkb:SH3D2C(gene name synonym) |
| Aliases for B | psi-mi:raph1_human(display_long) uniprotkb:RAPH1(gene name) psi-mi:RAPH1(display_short) uniprotkb:ALS2CR18(gene name synonym) uniprotkb:ALS2CR9(gene name synonym) uniprotkb:KIAA1681(gene name synonym) uniprotkb:LPD(gene name synonym) uniprotkb:PREL2(gene name synonym) uniprotkb:RMO1(gene name synonym) uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein(gene name synonym) uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein(gene name synonym) uniprotkb:Lamellipodin(gene name synonym) uniprotkb:Proline-rich EVH1 ligand 2(gene name synonym) uniprotkb:Protein RMO1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0416"(fluorescence microscopy) |
| First author | Vehlow et al. (2013) |
| Identifier of the publication | imex:IM-22206 pubmed:24076656 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0403"(colocalization) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9120387 imex:IM-22206-10 |
| Confidence score | intact-miscore:0.63 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f1e f1f f2 comment:"\"To identify the part of Lpd that interacts with the SH3 domain of endophilin, we generated different truncation mutants of Lpd tagged with mCherry (Figure 2A) and co‐expressed them with GFP‐endophilin A3 in HeLa cells. We scored colocalization of both proteins in cells in which the expression of endophilin A3 caused membrane tubulation. As expected, we did not observe colocalization of the two C‐terminal truncation mutants of Lpd (Lpd‐N1, Lpd‐N2) with endophilin A3, as these do not contain SH3 domain‐binding sites (Figure 2B and C). However, all N‐terminal truncated Lpd constructs containing proline‐rich regions colocalized with endophilin A3 (Figure 2B and C), suggesting that the endophilin SH3 domain binds to various proline‐rich regions in the Lpd sequence.\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-hela) taxid:9606(Homo sapiens HeLa epitheloid cervical carcinoma cell) |
| Parameters of the interaction | - |
| Creation date | 2014/02/06 |
| Update date | 2014/10/16 |
| negative Boolean value | false |
| Feature(s) for interactor A | green fluorescent protein tag:?-? |
| Feature(s) for interactor B | mcherry fluorescent protein tag:?-? |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Tag visualisation by fluorescence |
| Participant identification method for interactor B | Tag visualisation by fluorescence |