| Unique identifier for interactor A | uniprotkb:Q15393 |
| Unique identifier for interactor B | uniprotkb:P61978 |
| Alternative identifier for interactor A | intact:EBI-346977 uniprotkb:Q6NTI8 uniprotkb:Q96GC0 uniprotkb:Q9BPY2 uniprotkb:Q9UFX7 uniprotkb:Q9UJ29 ensembl:ENSP00000305790.5 |
| Alternative identifier for interactor B | intact:EBI-304185 intact:EBI-28971491 uniprotkb:Q07244 uniprotkb:Q15671 uniprotkb:Q59F98 uniprotkb:Q60577 uniprotkb:Q922Y7 uniprotkb:Q96J62 uniprotkb:Q5T6W4 ensembl:ENSP00000317788.4 ensembl:ENSP00000353552.5 ensembl:ENSP00000515619.1 ensembl:ENSP00000515654.1 ensembl:ENSP00000515655.1 ensembl:ENSP00000515656.1 ensembl:ENSP00000515661.1 intact:EBI-3440248 uniprotkb:Q6IBN1 |
| Aliases for A | psi-mi:sf3b3_human(display_long) uniprotkb:SF3B3(gene name) psi-mi:SF3B3(display_short) uniprotkb:KIAA0017(gene name synonym) uniprotkb:SAP130(gene name synonym) uniprotkb:Spliceosome-associated protein 130(gene name synonym) uniprotkb:Pre-mRNA-splicing factor SF3b 130 kDa subunit(gene name synonym) uniprotkb:STAF130(gene name synonym) |
| Aliases for B | psi-mi:hnrpk_human(display_long) uniprotkb:HNRNPK(gene name) psi-mi:HNRNPK(display_short) uniprotkb:HNRPK(gene name synonym) uniprotkb:Transformation up-regulated nuclear protein(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | Gumireddy et al. (2013) |
| Identifier of the publication | pubmed:23974796 imex:IM-22191 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0914"(association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9086436 imex:IM-22191-1 |
| Confidence score | intact-miscore:0.35 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f5b comment:"\"To investigate whether treRNA expression promoted RNP complex formation and the binding of eIF4G1 to the complex, we immunoprecipitated SF3B3 or eIF4G1 in MCF7 cells expressing treRNA or a vector control or a control lncRNA HAR1A. Co‐immunoprecipitation experiments showed that SF3B3 was associated with PUF60 in MCF7 cells expressing treRNA or a vector control or HAR1A (Figure 5B), confirming the results from previous publications that splicing factor 3B protein complex binds to PUF60 (Corsini et al, 2009; Prigge et al, 2009). Interestingly, SF3B3 interacted with hnRNP K, FXR1, FXR2, and eIF4G1 in MCF7 cells expressing treRNA, but not in MCF7 cells expressing a vector control or HAR1A, demonstrating that treRNA was required for the formation of treRNA RNP complex and its binding to eIF4G1 (Figure 5B).\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-mcf7) taxid:9606(Homo sapiens MCF-7 mammary adenocarcinoma cell) |
| Parameters of the interaction | - |
| Creation date | 2014/01/16 |
| Update date | 2025/07/31 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Predetermined participant |
| Participant identification method for interactor B | Western blot |