| Unique identifier for interactor A | uniprotkb:O14777 |
| Unique identifier for interactor B | uniprotkb:Q9UQE7 |
| Alternative identifier for interactor A | intact:EBI-715849 uniprotkb:Q6PJX2 ensembl:ENSP00000261597.4 |
| Alternative identifier for interactor B | intact:EBI-80718 uniprotkb:O60464 uniprotkb:Q5T482 uniprotkb:A8K156 ensembl:ENSP00000354720.5 |
| Aliases for A | psi-mi:ndc80_human(display_long) uniprotkb:Kinetochore protein Hec1(gene name synonym) uniprotkb:Kinetochore-associated protein 2(gene name synonym) uniprotkb:Highly expressed in cancer protein(gene name synonym) uniprotkb:Retinoblastoma-associated protein HEC(gene name synonym) uniprotkb:NDC80(gene name) psi-mi:NDC80(display_short) uniprotkb:HEC(gene name synonym) uniprotkb:KNTC2(gene name synonym) uniprotkb:HEC1(gene name synonym) |
| Aliases for B | psi-mi:smc3_human(display_long) uniprotkb:SMC3(gene name) psi-mi:SMC3(display_short) uniprotkb:BAM(gene name synonym) uniprotkb:SMC3L1(gene name synonym) uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym) uniprotkb:Chromosome-associated polypeptide(gene name synonym) uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym) uniprotkb:BMH(gene name synonym) uniprotkb:CSPG6(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0416"(fluorescence microscopy) |
| First author | Buheitel et al. (2013) |
| Identifier of the publication | imex:IM-22098 pubmed:23361318 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0403"(colocalization) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9104812 imex:IM-22098-1 |
| Confidence score | intact-miscore:0.27 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f4d comment:"\"Finally, the cells were fixed and processed for either in situ IF microscopy or chromosome spreading. Rapamycin (or DMSO as a control) was added at two alternative time points during the experiment, i.e., together with thymidine (‘Early’) or together with nocodazole (‘Late’). Notably, using a Smc1 antibody for IF, cohesin could be detected on Hec1‐positive, condensed chromatin if—and only if—FKBP‐Scc1 and Smc3‐FRB were expressed and rapamycin was present (Figure 4C). The same observation was made when transgenic cohesin was specifically visualised with an FRB antibody (Figure 4D).\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293) taxid:9606(Homo sapiens HEK293 embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2014/01/30 |
| Update date | 2024/09/12 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | fusion protein:c-c |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Immunostaining |
| Participant identification method for interactor B | Anti tag immunostaining |