| Unique identifier for interactor A | uniprotkb:Q15388 |
| Unique identifier for interactor B | uniprotkb:Q9BXM7 |
| Alternative identifier for interactor A | intact:EBI-711636 uniprotkb:A8K195 uniprotkb:Q498B3 uniprotkb:Q6IBT4 ensembl:ENSP00000355566.4 |
| Alternative identifier for interactor B | intact:EBI-2846068 uniprotkb:Q8N6T9 uniprotkb:Q8NBU3 uniprotkb:Q96DE4 ensembl:ENSP00000364204.3 |
| Aliases for A | psi-mi:tom20_human(display_long) uniprotkb:Outer mitochondrial membrane receptor Tom20(gene name synonym) uniprotkb:TOMM20(gene name) psi-mi:TOMM20(display_short) uniprotkb:KIAA0016(gene name synonym) uniprotkb:Mitochondrial 20 kDa outer membrane protein(gene name synonym) |
| Aliases for B | psi-mi:pink1_human(display_long) uniprotkb:PINK1(gene name) psi-mi:PINK1(display_short) uniprotkb:BRPK(gene name synonym) uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0416"(fluorescence microscopy) |
| First author | Fedorowicz et al. (2014) |
| Identifier of the publication | imex:IM-22096 pubmed:24357652 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0403"(colocalization) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9107541 imex:IM-22096-2 |
| Confidence score | intact-miscore:0.43 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f1b comment:"\"As illustrated by immunocytochemistry (Fig 1B), under basal conditions (DMSO control), there was marginal co‐localization between PINK1 and the mitochondrial marker TOM20 (co‐localization coefficient c = 0.16). In contrast, after 2 h exposure to valinomycin, there was a greater co‐localization between PINK1 and TOM20 (c = 0.58), with PINK1 immunoreactivity displaying a prominent punctate distribution. Following the incubation of cells with MG132, we saw cytosolic PINK1+ aggregates, many of which were TOM20−. Consequently, the mitochondrial co‐localization was limited (c = 0.32), again suggesting that a significant portion of PINK152 is localized in the cytosol.\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-hela) taxid:9606(Homo sapiens HeLa epitheloid cervical carcinoma cell) |
| Parameters of the interaction | - |
| Creation date | 2014/01/31 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Immunostaining |
| Participant identification method for interactor B | Immunostaining |