| Unique identifier for interactor A | uniprotkb:Q9UI08 |
| Unique identifier for interactor B | uniprotkb:Q9UQB8-4 |
| Alternative identifier for interactor A | intact:EBI-346653 uniprotkb:O95884 uniprotkb:Q7Z522 uniprotkb:Q8TBV1 uniprotkb:Q9UF25 uniprotkb:A8K105 uniprotkb:Q9UIC2 uniprotkb:B7Z3I5 ensembl:ENSP00000384720.2 |
| Alternative identifier for interactor B | intact:EBI-6174091 ensembl:ENSP00000315685.7 |
| Aliases for A | psi-mi:evl_human(display_long) uniprotkb:EVL(gene name) psi-mi:EVL(display_short) uniprotkb:RNB6(gene name synonym) uniprotkb:Ena/vasodilator-stimulated phosphoprotein-like(gene name synonym) |
| Aliases for B | psi-mi:q9uqb8-4(display_long) uniprotkb:BAIAP2-alpha(isoform synonym) uniprotkb:BAIAP2(gene name) psi-mi:BAIAP2(display_short) uniprotkb:Fas ligand-associated factor 3(gene name synonym) uniprotkb:Insulin receptor substrate p53/p58(gene name synonym) uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym) uniprotkb:Brain-specific angiogenesis inhibitor 1-associated protein 2(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0096"(pull down) |
| First author | Disanza et al. (2013) |
| Identifier of the publication | imex:IM-22092 pubmed:24076653 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-9201604 imex:IM-22092-2 |
| Confidence score | intact-miscore:0.44 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:sf1a comment:"\"IRSp53 associates with VASP, as well as EVL, through its SH3 domain (Supplementary Figure S1a–f) that contacts VASP on proline‐rich sites partially overlapping, but distinct from the Profilin binding sites (Supplementary Figure S1c and g).\"" comment:"\"Importantly, the VASP‐ΔPRD mutant, which is unable to bind to IRSp53 (Supplementary Figure S1e), and the IRSp53 W413G mutant, which lacks VASP binding ability (Supplementary Figure S1c), did not form heterocomplexes (Figure 1A, right, and data not shown). In contrast, a VASP mutant lacking the central three GP5 motifs (VASP‐ΔGP5), which retains IRSp53 binding ability, albeit with reduced affinity (Supplementary Figure S1d and f), was still able to hetero‐oligomerize upon addition of IRSp53 (Figure 1A, middle).\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2014/02/04 |
| Update date | 2025/03/31 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | glutathione s tranferase tag:?-? binding-associated region:381-433 |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Predetermined participant |