Curation Details
Interaction ID: IM-22075-8

Unique identifier for interactor Auniprotkb:B1Q2W9
Unique identifier for interactor Buniprotkb:P06748
Alternative identifier for interactor Aintact:EBI-9081051
Alternative identifier for interactor Bintact:EBI-78579
uniprotkb:A8K3N7
uniprotkb:B5BU00
uniprotkb:Q9UDJ7
uniprotkb:D3DQL6
uniprotkb:Q9BYG9
ensembl:ENSP00000296930.5
ensembl:ENSP00000428755.1
uniprotkb:P08693
uniprotkb:Q12826
uniprotkb:Q13440
uniprotkb:Q13441
uniprotkb:Q14115
uniprotkb:Q5EU94
uniprotkb:Q5EU95
uniprotkb:Q5EU96
uniprotkb:Q5EU97
uniprotkb:Q5EU98
uniprotkb:Q5EU99
uniprotkb:Q6V962
uniprotkb:Q8WTW5
uniprotkb:Q96AT6
uniprotkb:Q96DC4
uniprotkb:Q96EA5
Aliases for Apsi-mi:b1q2w9_hbvdr(display_long)
uniprotkb:Core antigen(gene name synonym)
uniprotkb:Core protein(gene name synonym)
uniprotkb:HBcAg(gene name synonym)
uniprotkb:p21.5(gene name synonym)
uniprotkb:C(gene name synonym)
uniprotkb:pre-C/C(gene name)
psi-mi:pre-C/C(display_short)
Aliases for Bpsi-mi:npm_human(display_long)
uniprotkb:NPM1(gene name)
psi-mi:NPM1(display_short)
uniprotkb:NPM(gene name synonym)
uniprotkb:Nucleolar phosphoprotein B23(gene name synonym)
uniprotkb:Numatrin(gene name synonym)
uniprotkb:Nucleolar protein NO38(gene name synonym)
Interaction detection methodspsi-mi:"MI:0006"(anti bait coimmunoprecipitation)
First authorJeong et al. (2014)
Identifier of the publicationimex:IM-22075
pubmed:24462683
NCBI Taxonomy identifier for interactor Ataxid:106820(hbvdr)
taxid:106820(Hepatitis B virus subtype adr)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-9081333
imex:IM-22075-8
Confidence scoreintact-miscore:0.64
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f4a f4b
comment:"\"we used co11 immunoprecipitation analysis to examine whether oligomerization of B23 was necessary for its interaction with core protein. Given that the B23 mutant C21F is defective in oligomerization [19], C21F was used as a monomer in this analysis. The HBV core dimer could interact only with B23 oligomer but not with B23 monomer (Fig. 4A). These showed that the oligomerization of B23 was mandatory for its interaction with core protein. Consistent with the data, C21F (a monomeric form of B23) could not promote capsid assembly (Fig. 4B).\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2014/01/11
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:1-149
Feature(s) for interactor Bmutation disrupting interaction:21-21
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot