Curation Details
Interaction ID: IM-22074-4

Unique identifier for interactor Auniprotkb:P25963
Unique identifier for interactor Buniprotkb:P23396
Alternative identifier for interactor Aintact:EBI-307386
uniprotkb:B2R8L6
ensembl:ENSP00000216797.6
Alternative identifier for interactor Bintact:EBI-351193
uniprotkb:B2R7N5
uniprotkb:J3KN86
uniprotkb:Q498B5
ensembl:ENSP00000433821.1
ensembl:ENSP00000434643.1
ensembl:ENSP00000436971.1
uniprotkb:Q8NI95
Aliases for Apsi-mi:ikba_human(display_long)
uniprotkb:NFKBIA(gene name)
psi-mi:NFKBIA(display_short)
uniprotkb:IKBA(gene name synonym)
uniprotkb:MAD3(gene name synonym)
uniprotkb:NFKBI(gene name synonym)
uniprotkb:I-kappa-B-alpha(gene name synonym)
uniprotkb:Major histocompatibility complex enhancer-binding protein MAD3(gene name synonym)
Aliases for Bpsi-mi:rs3_human(display_long)
uniprotkb:RPS3(gene name)
psi-mi:RPS3(display_short)
uniprotkb:40S ribosomal protein S3(gene name synonym)
uniprotkb:OK/SW-cl.26(orf name)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorStanborough et al. (2014)
Identifier of the publicationpubmed:24457201
imex:IM-22074
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-9081560
imex:IM-22074-4
Confidence scoreintact-miscore:0.68
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f2 f3c
comment:"\"Strikingly, pull-down of IκBα resulted in co-purification of significant amounts of RPS3 (Fig. 2). However, very little RPS3 co-purified with p65(1-311). These data clearly demonstrate a strong direct interaction between RPS3 and IκBα. In contrast, the weak binding of RPS3 to p65 suggests that these two proteins engage in a rather transient interaction.\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:83333(ecoli)
taxid:83333("Escherichia coli (strain K12)")
Parameters of the interaction-
Creation date2014/01/11
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Aflag tag:?-?
binding-associated region:67-302
Feature(s) for interactor Bhis tag:?-?
binding-associated region:91-199
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AAnti tag western blot
Participant identification method for interactor BAnti tag western blot