Unique identifier for interactor A | uniprotkb:P37840 |
Unique identifier for interactor B | uniprotkb:P37840 |
Alternative identifier for interactor A | intact:EBI-985879 uniprotkb:A8K2A4 ensembl:ENSP00000338345.3 ensembl:ENSP00000378437.1 ensembl:ENSP00000378442.4 ensembl:ENSP00000422238.1 ensembl:ENSP00000426955.1 ensembl:ENSP00000500990.1 uniprotkb:Q13701 uniprotkb:Q4JHI3 uniprotkb:Q6IAU6 |
Alternative identifier for interactor B | intact:EBI-985879 uniprotkb:A8K2A4 ensembl:ENSP00000338345.3 ensembl:ENSP00000378437.1 ensembl:ENSP00000378442.4 ensembl:ENSP00000422238.1 ensembl:ENSP00000426955.1 ensembl:ENSP00000500990.1 uniprotkb:Q13701 uniprotkb:Q4JHI3 uniprotkb:Q6IAU6 |
Aliases for A | psi-mi:syua_human(display_long) uniprotkb:Non-A beta component of AD amyloid(gene name synonym) uniprotkb:Non-A4 component of amyloid precursor(gene name synonym) uniprotkb:SNCA(gene name) psi-mi:SNCA(display_short) uniprotkb:NACP(gene name synonym) uniprotkb:PARK1(gene name synonym) |
Aliases for B | psi-mi:syua_human(display_long) uniprotkb:Non-A beta component of AD amyloid(gene name synonym) uniprotkb:Non-A4 component of amyloid precursor(gene name synonym) uniprotkb:SNCA(gene name) psi-mi:SNCA(display_short) uniprotkb:NACP(gene name synonym) uniprotkb:PARK1(gene name synonym) |
Interaction detection methods | psi-mi:"MI:0051"(fluorescence technology) |
First author | Lorenzen et al. (2013) |
Identifier of the publication | pubmed:24374342 imex:IM-22024 |
NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
Interaction types | psi-mi:"MI:0407"(direct interaction) |
Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
Interaction identifier(s) in the corresponding source database | intact:EBI-9063624 imex:IM-22024-1 |
Confidence score | intact-miscore:0.99 |
Complex expansion | - |
Biological role A | Unspecified role |
Biological role B | Unspecified role |
Experimental role A | Neutral component |
Experimental role B | Neutral component |
Interactor type A | Protein |
Interactor type B | Protein |
Annotations for the interaction | figure legend:f1c t1 sf1 comment:"\"All mutants formed amyloid fibrils in vitro both in an SDS-induced and a shaking-induced fibrillation assay (Fig. S1).\"" comment:"\"ANS fluorescence was not affected by monomers, but oligomers induced both a blue shift and an intensity increase (Fig. 1C). The monomer averaged emission fluorescence maximum <λmax monomer> = 510 nm while < λmax oligomer> = 474 nm, indicating formation of hydrophobic patches on the oligomers. λmax oligomer varies little (472.5- 477.5 nm, Table 1), indicating small variations in hydrophobicity.\"" comment:All mutants were able to form oligomers, wt, Del2 and Del2-5 at comparable levels whereas we obtained a significant lower yield of Del2-11 oligomers. The RH of the oligomers, as determined by DLS, are comparable. Thus, deletions in the first 11 residues of the N-terminal affect neither oligomer nor fibril gross structure. full coverage:Only protein-protein interactions curation depth:imex curation |
NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
Parameters of the interaction | - |
Creation date | 2013/12/17 |
Update date | 2014/10/16 |
negative Boolean value | false |
Feature(s) for interactor A | - |
Feature(s) for interactor B | - |
Stoichiometry for interactor A | - |
Stoichiometry for interactor B | - |
Participant identification method for interactor A | Predetermined participant |
Participant identification method for interactor B | Predetermined participant |