| Unique identifier for interactor A | uniprotkb:Q8NC51 |
| Unique identifier for interactor B | uniprotkb:P09651 |
| Alternative identifier for interactor A | intact:EBI-523558 intact:EBI-1058614 uniprotkb:Q5VU20 uniprotkb:Q5VU22 ensembl:ENSP00000360034.2 uniprotkb:Q8WUH0 uniprotkb:Q96SE2 uniprotkb:Q9BTY3 uniprotkb:Q9BUM4 uniprotkb:Q9Y367 uniprotkb:Q9Y4S3 uniprotkb:Q5VU19 |
| Alternative identifier for interactor B | intact:EBI-352662 uniprotkb:A8K4Z8 intact:EBI-2556572 ensembl:ENSP00000341826.7 ensembl:ENSP00000503610.1 intact:EBI-21353669 uniprotkb:Q3MIB7 uniprotkb:Q6PJZ7 |
| Aliases for A | psi-mi:serb1_human(display_long) uniprotkb:PAI1 RNA-binding protein 1(gene name synonym) uniprotkb:SERBP1(gene name) psi-mi:SERBP1(display_short) uniprotkb:PAIRBP1(gene name synonym) uniprotkb:Plasminogen activator inhibitor 1 RNA-binding protein(gene name synonym) uniprotkb:CGI-55(orf name) |
| Aliases for B | psi-mi:roa1_human(display_long) uniprotkb:HNRNPA1(gene name) psi-mi:HNRNPA1(display_short) uniprotkb:HNRPA1(gene name synonym) uniprotkb:Helix-destabilizing protein(gene name synonym) uniprotkb:Single-strand RNA-binding protein(gene name synonym) uniprotkb:hnRNP core protein A1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0007"(anti tag coimmunoprecipitation) |
| First author | Yu-Jen et al. (2013) |
| Identifier of the publication | pubmed:24205981 imex:IM-21716 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0914"(association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-8844408 imex:IM-21716-6 |
| Confidence score | intact-miscore:0.43 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:SF1 comment:"\"We first showed that hnRNPA1 co-immunoprecipitated with FLAG-tagged SERBP1 (Fig. 1A). The interaction requires RNA because addition of RNase to the HeLa cell extract before the immunoprecipitation totally blocked the interaction. On the other hand, interaction of PRMT1 that can directly interact with SERBP1 [17] was not influenced by RNase treatment.\"" comment:"\"The middle RG segment that is important for SERBP1 nuclear localization [2] is not required nor sufficient for the interaction, because RG-deletion interacts with hnRNPA1 or FMRP, while only very weak interaction can be detected for the middle segment (151-270) containing the RG sequences (Fig.S1). In comparison, SERBP1 constructs with N-terminal deletions (151-387) or the N-terminal domain alone (1-150) showed hnRNPA1 or FMRP interaction, indicating that this segment is not required but sufficient for the interaction (Fig. S1).\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-hela) taxid:9606(Homo sapiens HeLa epitheloid cervical carcinoma cell) |
| Parameters of the interaction | - |
| Creation date | 2013/11/06 |
| Update date | 2014/10/16 |
| negative Boolean value | false |
| Feature(s) for interactor A | flag tag:?-? sufficient binding region:1-150 |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Anti tag western blot |
| Participant identification method for interactor B | Western blot |