Curation Details
Interaction ID: IM-21716-4

Unique identifier for interactor Auniprotkb:Q8NC51
Unique identifier for interactor Buniprotkb:P31483
Alternative identifier for interactor Aintact:EBI-523558
intact:EBI-1058614
uniprotkb:Q5VU20
uniprotkb:Q5VU22
ensembl:ENSP00000360034.2
uniprotkb:Q8WUH0
uniprotkb:Q96SE2
uniprotkb:Q9BTY3
uniprotkb:Q9BUM4
uniprotkb:Q9Y367
uniprotkb:Q9Y4S3
uniprotkb:Q5VU19
Alternative identifier for interactor Bintact:EBI-1387216
ensembl:ENSP00000401371.2
uniprotkb:Q96B58
uniprotkb:Q53SS9
Aliases for Apsi-mi:serb1_human(display_long)
uniprotkb:PAI1 RNA-binding protein 1(gene name synonym)
uniprotkb:SERBP1(gene name)
psi-mi:SERBP1(display_short)
uniprotkb:PAIRBP1(gene name synonym)
uniprotkb:Plasminogen activator inhibitor 1 RNA-binding protein(gene name synonym)
uniprotkb:CGI-55(orf name)
Aliases for Bpsi-mi:tia1_human(display_long)
uniprotkb:TIA1(gene name)
psi-mi:TIA1(display_short)
uniprotkb:p40-TIA-1(gene name synonym)
uniprotkb:RNA-binding protein TIA-1(gene name synonym)
uniprotkb:T-cell-restricted intracellular antigen-1(gene name synonym)
uniprotkb:Nucleolysin TIA-1 isoform p40(gene name synonym)
Interaction detection methodspsi-mi:"MI:0416"(fluorescence microscopy)
First authorYu-Jen et al. (2013)
Identifier of the publicationpubmed:24205981
imex:IM-21716
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0403"(colocalization)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8844374
imex:IM-21716-4
Confidence scoreintact-miscore:0.27
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role AUnspecified role
Experimental role BUnspecified role
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F2B F3 T1 SF2 ST1
comment:"\"The SERBP1 and TIA1 double positive SGs reduced from 70% for the full-length to about 50% for the truncated ones. Furthermore, the number of SERBP1-positive SGs per cell and SERBP1-positive area in SGs also reduced in the deletions (Table S1). The results show that less SERBP1 deletion proteins can be recruited to the SGs.\""
comment:"\"We then analyzed the single domain constructs (1-150, 151-270, 271-387). All of the three single domains of SERBP1 could relocalize to cytoplasmic SGs, however, with even fewer cells containing the SERBP1-positive SGs (~40%) and fewer SGs as SERBP1 positive (~35%) (Fig. S2 and Table 1). The results indicate that any segment of SERBP1 is sufficient for the SG localization but complete SG distribution requires the cooperation of more than one domain.\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-hela)
taxid:9606(Homo sapiens HeLa epitheloid cervical carcinoma cell)
Parameters of the interaction-
Creation date2013/11/06
Update date2014/10/16
negative Boolean valuefalse
Feature(s) for interactor Aenhanced green fluorescent protein tag:?-?
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor ATag visualisation by fluorescence
Participant identification method for interactor BImmunostaining