Curation Details
Interaction ID: IM-21714-1

Unique identifier for interactor Auniprotkb:Q13485
Unique identifier for interactor Buniprotkb:Q03135
Alternative identifier for interactor Aintact:EBI-347263
ensembl:ENSP00000341551.3
ensembl:ENSP00000381452.1
ensembl:ENSP00000464772.2
ensembl:ENSP00000465874.2
ensembl:ENSP00000465878.2
ensembl:ENSP00000466934.2
uniprotkb:A8K405
Alternative identifier for interactor Bintact:EBI-603614
uniprotkb:Q9UGP1
uniprotkb:Q9UNG1
uniprotkb:Q9UQH6
ensembl:ENSP00000339191.2
Aliases for Apsi-mi:smad4_human(display_long)
uniprotkb:SMAD4(gene name)
psi-mi:SMAD4(display_short)
uniprotkb:DPC4(gene name synonym)
uniprotkb:MADH4(gene name synonym)
uniprotkb:SMAD family member 4(gene name synonym)
uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)
Aliases for Bpsi-mi:cav1_human(display_long)
uniprotkb:CAV1(gene name)
psi-mi:CAV1(display_short)
uniprotkb:CAV(gene name synonym)
Interaction detection methodspsi-mi:"MI:0416"(fluorescence microscopy)
First authorYong et al. (2013)
Identifier of the publicationpubmed:24211445
imex:IM-21714
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0403"(colocalization)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-8838613
imex:IM-21714-1
Confidence scoreintact-miscore:0.27
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role AUnspecified role
Experimental role BUnspecified role
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f2a
comment:"\"Using immunofluorescence imaging of fixed cells, we studied the potential colocalization between SMAD4 and clathrin or caveolin-1. Indeed, there were regions on the cell membrane were the proteins co-localized (Fig. 2A). The partition coefficient for co-localization of SMAD4 with clathrin or caveolin-1 was approximately 29% and 44%, respectively.\""
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:9606(human-mda_mb_231)
taxid:9606(Homo sapiens MDA-MB-231 breast adenocarcinoma cell)
Parameters of the interaction-
Creation date2013/10/30
Update date2024/11/22
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AImmunostaining
Participant identification method for interactor BImmunostaining