Curation Details
Interaction ID: IM-21668-22

Unique identifier for interactor Auniprotkb:O95863
Unique identifier for interactor Buniprotkb:P16104
Alternative identifier for interactor Aintact:EBI-1045459
uniprotkb:B2R842
ensembl:ENSP00000244050.2
uniprotkb:Q9P113
uniprotkb:Q9UBP7
uniprotkb:Q9UHH7
Alternative identifier for interactor Bintact:EBI-494830
uniprotkb:Q4ZGJ7
uniprotkb:Q6IAS5
ensembl:ENSP00000364310.1
ensembl:ENSP00000434024.1
Aliases for Apsi-mi:snai1_human(display_long)
uniprotkb:Protein snail homolog 1(gene name synonym)
uniprotkb:SNAI1(gene name)
psi-mi:SNAI1(display_short)
uniprotkb:SNAH(gene name synonym)
Aliases for Bpsi-mi:h2ax_human(display_long)
uniprotkb:H2AX(gene name)
psi-mi:H2AX(display_short)
uniprotkb:H2AFX(gene name synonym)
uniprotkb:Histone H2A.X(gene name synonym)
Interaction detection methodspsi-mi:"MI:0416"(fluorescence microscopy)
First authorArroyo et al. (2015)
Identifier of the publicationpubmed:25640309
imex:IM-21668
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0403"(colocalization)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-10110819
imex:IM-21668-22
Confidence scoreintact-miscore:0.27
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f5d
comment:"\"Hence, U2OS cells overexpressing our candidate genes were analyzed for IRIF formation and colocalization with γH2AX 1 h and 6 h post-irradiation (see Materials and Methods) [46]. We observed that both RNF20 and SNAI1 progressively re-localize into IRIF upon the induction of DNA damage by IR (Fig. 5c and d), providing further support that the recruitment of these proteins to IRIF may be indicative of a role in DSB repair or signaling.\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-u2os)
taxid:9606(Homo sapiens U2OS osteosarcoma cell)
Parameters of the interaction-
Creation date2013/12/18
Update date2015/02/10
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AImmunostaining
Participant identification method for interactor BImmunostaining