| Unique identifier for interactor A | uniprotkb:Q13526 |
| Unique identifier for interactor B | uniprotkb:Q13950 |
| Alternative identifier for interactor A | intact:EBI-714158 uniprotkb:A8K4V9 ensembl:ENSP00000247970.5 ensembl:ENSP00000466962.1 uniprotkb:Q53X75 |
| Alternative identifier for interactor B | intact:EBI-976402 ensembl:ENSP00000360493.1 ensembl:ENSP00000495497.1 intact:EBI-28971669 uniprotkb:O14614 uniprotkb:O14615 uniprotkb:O95181 |
| Aliases for A | psi-mi:pin1_human(display_long) uniprotkb:Rotamase Pin1(gene name synonym) uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym) uniprotkb:PIN1(gene name) psi-mi:PIN1(display_short) |
| Aliases for B | psi-mi:runx2_human(display_long) uniprotkb:Oncogene AML-3(gene name synonym) uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym) uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym) uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym) uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym) uniprotkb:Core-binding factor subunit alpha-1(gene name synonym) uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym) uniprotkb:RUNX2(gene name) psi-mi:RUNX2(display_short) uniprotkb:AML3(gene name synonym) uniprotkb:CBFA1(gene name synonym) uniprotkb:OSF2(gene name synonym) uniprotkb:PEBP2A(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0096"(pull down) |
| First author | Lee et al. (2013) |
| Identifier of the publication | imex:IM-21648 pubmed:24113655 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-8771960 imex:IM-21648-3 |
| Confidence score | intact-miscore:0.59 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f3b f3d comment:"\"We tested Ser or Tyr residue (including Ser16) substitution mutants of Pin1 (Fig. 3A) for the interaction with Runx2. Substitution of Ser16 to Ala abolished the binding of Pin1 to Runx2 (Fig. 3C). Tyr to Ala substitution (Y23A or Y24A) in the WW domain also significantly reduced the interaction with Runx2, whereas same substitution in the PPIase catalytic domain (Y94A) did not have any noticeable effect (Fig. 3D). Collectively, these results suggest that the WW domain of Pin1 is important for binding to Runx2\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2013/09/25 |
| Update date | 2014/10/16 |
| negative Boolean value | false |
| Feature(s) for interactor A | glutathione s tranferase tag:?-? mutation decreasing interaction:24-24 |
| Feature(s) for interactor B | binding-associated region:92-513 myc tag:?-? |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Predetermined participant |
| Participant identification method for interactor B | Anti tag western blot |