| Unique identifier for interactor A | uniprotkb:O95292 |
| Unique identifier for interactor B | uniprotkb:Q6PEC3 |
| Alternative identifier for interactor A | intact:EBI-1188298 uniprotkb:O95293 uniprotkb:Q9P0H0 uniprotkb:A2A2F2 ensembl:ENSP00000417175.1 |
| Alternative identifier for interactor B | intact:EBI-8804483 ensembl:ENSRNOP00000045414.5 |
| Aliases for A | psi-mi:vapb_human(display_long) uniprotkb:VAPB(gene name) psi-mi:VAPB(display_short) uniprotkb:UNQ484/PRO983(orf name) |
| Aliases for B | psi-mi:yif1b_rat(display_long) uniprotkb:Yif1b(gene name) psi-mi:Yif1b(display_short) uniprotkb:YIP1-interacting factor homolog B(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0416"(fluorescence microscopy) |
| First author | Kuijpers et al. (2013) |
| Identifier of the publication | imex:IM-21642 pubmed:23736259 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:10116(rat) taxid:10116("Rattus norvegicus (Rat)") |
| Interaction types | psi-mi:"MI:0403"(colocalization) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-8804560 imex:IM-21642-6 |
| Confidence score | intact-miscore:0.46 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Unspecified role |
| Experimental role B | Unspecified role |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f1g comment:"\"To further confirm the interaction between VAPB and YIF1A, we performed immunofluorescence experiments in COS-7 cells. HA-YIF1A co-localized with both endogenous VAPB and co-transfected myc-VAPB, which as previously demonstrated localize to the ER (Nishimura et al, 2004; Kanekura et al, 2006; Teuling et al, 2007; Kim et al, 2010; Papiani et al, 2012) (Figure 1D and E). Significantly, HA-YIF1A also co-distributes with ALS-linked mutant VAPB-P56S and VAPA-P56S (Figure 1F and H), which accumulates in small spherical inclusions (Nishimura et al, 2004; Kanekura et al, 2006; Teuling et al, 2007; Kim et al, 2010; Papiani et al, 2012). Likewise also YIF1B was recruited to mutant VAPA/B inclusion (Figure 1G and I). Together, these results show that YIF1A/B interacts with VAPA/B family proteins.\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9534(chlae-cos_7) taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) |
| Parameters of the interaction | - |
| Creation date | 2013/10/17 |
| Update date | 2025/03/31 |
| negative Boolean value | false |
| Feature(s) for interactor A | myc tag:?-? |
| Feature(s) for interactor B | flag tag:?-? |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Anti tag immunostaining |
| Participant identification method for interactor B | Anti tag immunostaining |