| Unique identifier for interactor A | uniprotkb:O95292 |
| Unique identifier for interactor B | uniprotkb:O95070 |
| Alternative identifier for interactor A | intact:EBI-1188298 ensembl:ENSP00000417175.1 uniprotkb:O95293 uniprotkb:Q9P0H0 uniprotkb:A2A2F2 |
| Alternative identifier for interactor B | intact:EBI-2799703 uniprotkb:Q9BVD0 uniprotkb:A6NM00 uniprotkb:Q96G83 ensembl:ENSP00000366098.4 |
| Aliases for A | psi-mi:vapb_human(display_long) uniprotkb:VAPB(gene name) psi-mi:VAPB(display_short) uniprotkb:UNQ484/PRO983(orf name) |
| Aliases for B | psi-mi:yif1a_human(display_long) uniprotkb:54TM(gene name synonym) uniprotkb:HYIF1P(gene name synonym) uniprotkb:YIF1(gene name synonym) uniprotkb:54TMp(gene name synonym) uniprotkb:YIP1-interacting factor homolog A(gene name synonym) uniprotkb:YIF1A(gene name) psi-mi:YIF1A(display_short) |
| Interaction detection methods | psi-mi:"MI:0416"(fluorescence microscopy) |
| First author | Kuijpers et al. (2013) |
| Identifier of the publication | imex:IM-21642 pubmed:23736259 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0403"(colocalization) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-8804789 imex:IM-21642-11 |
| Confidence score | intact-miscore:0.60 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Unspecified role |
| Experimental role B | Unspecified role |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f2j f2k f2l sf1 comment:"\"GxxxG motifs are known to facilitate interactions between transmembrane helices and mediate the assembly of the transmembrane helices in VAPB (Kim et al, 2010). However, disruption of these motifs in YIF1A did not interfere with VAPB binding (Figure 2I). These data were confirmed by immunofluorescence in COS-7 cells (Figure 2J–L; Supplementary Figure S1). The results show that the first two transmembrane domains of YIF1A are important for VAPB binding but that this binding does not depend on GxxxG motifs. Together, these data indicate that the transmembrane domains of both VAPB and YIF1A are important for their interaction.\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9534(chlae-cos_7) taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) |
| Parameters of the interaction | - |
| Creation date | 2013/10/17 |
| Update date | 2024/11/30 |
| negative Boolean value | false |
| Feature(s) for interactor A | myc tag:?-? |
| Feature(s) for interactor B | green fluorescent protein tag:?-? binding-associated region:131-293 |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Anti tag immunostaining |
| Participant identification method for interactor B | Tag visualisation by fluorescence |