| Unique identifier for interactor A | uniprotkb:P28799 |
| Unique identifier for interactor B | uniprotkb:P20333 |
| Alternative identifier for interactor A | intact:EBI-747754 uniprotkb:Q53Y88 uniprotkb:Q540U8 uniprotkb:D3DX55 uniprotkb:Q53HQ8 uniprotkb:Q9H8S1 ensembl:ENSP00000053867.2 uniprotkb:P23781 uniprotkb:P23782 uniprotkb:P23783 uniprotkb:P23784 uniprotkb:Q9BWE7 uniprotkb:Q9UCH0 |
| Alternative identifier for interactor B | intact:EBI-358983 uniprotkb:B1AJZ3 ensembl:ENSP00000365435.3 uniprotkb:Q16042 uniprotkb:Q6YI29 uniprotkb:Q9UIH1 |
| Aliases for A | psi-mi:grn_human(display_long) uniprotkb:Proepithelin(gene name synonym) uniprotkb:GRN(gene name) psi-mi:GRN(display_short) uniprotkb:Acrogranin(gene name synonym) uniprotkb:Epithelin precursor(gene name synonym) uniprotkb:Glycoprotein of 88 Kda(gene name synonym) uniprotkb:Granulin precursor(gene name synonym) uniprotkb:PC cell-derived growth factor(gene name synonym) |
| Aliases for B | psi-mi:tnr1b_human(display_long) uniprotkb:TNFRSF1B(gene name) psi-mi:TNFRSF1B(display_short) uniprotkb:TNFBR(gene name synonym) uniprotkb:TNFR2(gene name synonym) uniprotkb:Tumor necrosis factor receptor 2(gene name synonym) uniprotkb:Tumor necrosis factor receptor type II(gene name synonym) uniprotkb:p75(gene name synonym) uniprotkb:p80 TNF-alpha receptor(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0892"(solid phase assay) |
| First author | Jian et al. (2013) |
| Identifier of the publication | imex:IM-21538 pubmed:24070898 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-8759870 imex:IM-21538-6 |
| Confidence score | intact-miscore:0.64 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f3b comment:"\"To test this hypothesis, PGRN was pretreated with 10mM DTT, which is known to disturb the formation of disulfide bonds in PGRN and in turn affects its folding, and then the binding of PGRN to TNFR2 and Sortilin were measured using solid phase binding. DTT treatment completely abolished the binding of PGRN to TNFR2 (Fig. 3A). In marked contrast, the binding of PGRN to Sortilin was significantly enhanced by DTT treatment (Fig. 3B).\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2013/09/12 |
| Update date | 2014/10/16 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Enzyme linked immunosorbent assay |
| Participant identification method for interactor B | Enzyme linked immunosorbent assay |