| Unique identifier for interactor A | uniprotkb:P01375 |
| Unique identifier for interactor B | uniprotkb:P19438 |
| Alternative identifier for interactor A | intact:EBI-359977 uniprotkb:O43647 uniprotkb:Q9P1Q2 uniprotkb:Q9UIV3 ensembl:ENSP00000365290.3 ensembl:ENSP00000372988.4 ensembl:ENSP00000389490.2 ensembl:ENSP00000389492.2 ensembl:ENSP00000392858.2 ensembl:ENSP00000398698.2 ensembl:ENSP00000410668.2 |
| Alternative identifier for interactor B | intact:EBI-299451 uniprotkb:A8K4X3 uniprotkb:B2RDE4 uniprotkb:B3KPQ1 uniprotkb:B4DQB7 uniprotkb:B4E309 uniprotkb:Q9UCA4 ensembl:ENSP00000162749.2 uniprotkb:D3DUR1 uniprotkb:B5M0B5 |
| Aliases for A | psi-mi:tnfa_human(display_long) uniprotkb:TNF(gene name) psi-mi:TNF(display_short) uniprotkb:TNFA(gene name synonym) uniprotkb:TNFSF2(gene name synonym) uniprotkb:TNF-alpha(gene name synonym) uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym) uniprotkb:Cachectin(gene name synonym) |
| Aliases for B | psi-mi:tnr1a_human(display_long) uniprotkb:TNFRSF1A(gene name) psi-mi:TNFRSF1A(display_short) uniprotkb:TNFAR(gene name synonym) uniprotkb:TNFR1(gene name synonym) uniprotkb:p60(gene name synonym) uniprotkb:Tumor necrosis factor receptor 1(gene name synonym) uniprotkb:Tumor necrosis factor receptor type I(gene name synonym) uniprotkb:p55(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0107"(surface plasmon resonance) |
| First author | Jian et al. (2013) |
| Identifier of the publication | imex:IM-21538 pubmed:24070898 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-8759739 imex:IM-21538-3 |
| Confidence score | intact-miscore:0.93 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:t1 f2a f2c comment:"\"As shown in Fig. 2A and C, TNFα binds to TNFR on COOH1 and COOHV chips in SensiQ methods. When tested on the COOH1 chip, the same chip used in our previous study [26], PGRN from Adipogen shows high binding affinity to both TNFR1 and TNFR2 (Fig. 2D). Consistent with our previous study [26], PGRN shows selectively higher binding affinity to TNFR2 than to TNFR1. However, when switched to COOHV chip, PGRN fails to bind to TFNR (Fig. 2B). These data were repeated in three individual experiments. Furthermore PGRN fails to bind to TNFR1 and TNFR2 in CM5 chips in Biacore, which is the same chip used in Chen’s study [29]. As summarized in Table 1, the successful demonstration of the binding of PGRN to TNFR1 and TNFR2 in surface plasmon resonance is highly dependent upon the chips used.\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | kd:3.4x10^-9(molar) kd:1.2x10^-9(molar) kd:2.3x10^-9(molar) |
| Creation date | 2013/09/12 |
| Update date | 2014/10/16 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Predetermined participant |
| Participant identification method for interactor B | Predetermined participant |